We provide an updated framework of the current approaches to define and diagnose
preeclampsia. Disease modifying therapies (in particular, targeting the angiogenic pathway) …

Preeclampsia (PE) is a high-prevalence pregnancy disease characterized by placental
insufficiency, gestational hypertension, and proteinuria. Overexpression of the A isoform of …

Preeclampsia (PE) is a pregnancy-specific syndrome affecting 5–7% of patients. There is no
effective treatment available. Early abnormal placental development is associated with …

To clarify the differences in the clinical application scope of Chrysanthemum morifolium
flower (CMF) and Chrysanthemum indicum flower (CIF), two herbs of similar origin, an …

The cofactor tetrahydrobiopterin (BH4) is a critical regulator of nitric oxide synthase (NOS)
function and redox signaling, with reduced BH4 implicated in multiple cardiovascular …

Background Recurrent pregnancy loss (RPL) affects women's reproductive health seriously,
with immune dysfunction playing a key role in its cause, yet the exact mechanisms remain …

BACKGROUND: Folate intake during pregnancy is essential for fetal development and
maternal health. However, the specific effects of folic acid (FA) and 5-methyl-(6S) …

Dopa and tetrahydrobiopterin (BH4) supplementation are recommended therapies for the
dopa-responsive dystonia caused by GTP cyclohydrolase 1 (GCH1, also known as GTPCH) …

Background and purpose Pregnancy-associated vascular remodelling is essential for both
maternal and fetal health. We have previously shown that maternal endothelial cell …

The cofactor tetrahydrobiopterin (BH 4) is a critical regulator of nitric oxide synthase (NOS)
function and redox signaling, with reduced BH 4 implicated in multiple cardiovascular …