Acidic extracellular pH is a major feature of tumor tissue, extracellular acidification being
primarily considered to be due to lactate secretion from anaerobic glycolysis …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

Tissue acidosis is a common feature of many painful conditions. Protons are indeed among
the first factors released by injured tissues, inducing a local pH fall that depolarizes …

Abstract Development of the pharmacology of Acid-Sensing Ion Channels (ASICs) has
become a key challenge to study their structure, their molecular and cellular functions and …

Electrical excitation of peripheral somatosensory nerves is a first step in generation of most
pain signals in mammalian nervous system. Such excitation is controlled by an intricate set …

Inflammatory pain results from the increased excitability of peripheral nociceptive sensory
fibres produced by the action of inflammatory mediators. This excitatory effect, in turn, is a …

Low pH in tissue can evoke pain in animals and humans, and is an important factor in
hyperalgesia. Research has also implicated acidosis in psychiatric and neurological …

BACKGROUND AND PURPOSE Inflammatory pain is triggered by activation of pathways
leading to the release of mediators such as bradykinin, prostaglandins, interleukins, ATP …

Study design: This is a narrative review of the literature. Objectives: This review aims to be
useful in identifying therapeutic targets. It focuses on the molecular and biochemical …

The aim of this study was to evaluate the antinociceptive effect of Kaempferol-3-O-rutinoside
(KR), isolated from the plant Ouratea fieldingiana, on the orofacial nociception and possible …