Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis

AS Nagle, S Khare, AB Kumar, F Supek… - Chemical …, 2014 - ACS Publications
Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

Predictors of visceral leishmaniasis relapse in HIV-infected patients: a systematic review

GF Cota, MR de Sousa, A Rabello - PLoS neglected tropical …, 2011 - journals.plos.org
Background and Objectives Visceral leishmaniasis (VL) is a common complication in AIDS
patients living in Leishmania-endemic areas. Although antiretroviral therapy has changed …

Diagnosis and treatment of leishmaniasis: clinical practice guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical …

N Aronson, BL Herwaldt, M Libman… - Clinical infectious …, 2016 - academic.oup.com
It is important to realize that leishmaniasis guidelines cannot always account for individual
variation among patients. They are not intended to supplant physician judgment with respect …

Mycetoma: experience of 482 cases in a single center in Mexico

A Bonifaz, A Tirado-Sánchez, L Calderón… - PLoS neglected …, 2014 - journals.plos.org
Mycetoma is a chronic granulomatous disease. It is classified into eumycetoma caused by
fungi and actinomycetoma due to filamentous actinomycetes. Mycetoma can be found in …

Visceral leishmaniasis and HIV coinfection in East Africa

E Diro, L Lynen, K Ritmeijer, M Boelaert… - PLoS neglected …, 2014 - journals.plos.org
Visceral Leishmaniasis (VL) is an important protozoan opportunistic disease in HIV patients
in endemic areas. East Africa is second to the Indian subcontinent in the global VL caseload …

Visceral leishmaniasis in the Indian subcontinent: modelling epidemiology and control

A Stauch, RR Sarkar, A Picado, B Ostyn… - PLoS neglected …, 2011 - journals.plos.org
Background In the Indian subcontinent, about 200 million people are at risk of developing
visceral leishmaniasis (VL). In 2005, the governments of India, Nepal and Bangladesh …

[HTML][HTML] Changes in the epidemiology of visceral leishmaniasis in Brazil from 2001 to 2014

LL Reis, AAS Balieiro, FR Fonseca… - Revista da Sociedade …, 2017 - SciELO Brasil
INTRODUCTION Visceral leishmaniasis (VL) is a neglected disease, with territorial
expansion and regional differences in Brazil that require explanation. This study aimed to …

Species-directed therapy for leishmaniasis in returning travellers: a comprehensive guide

CJ Hodiamont, PA Kager, A Bart… - PLoS neglected …, 2014 - journals.plos.org
Background Leishmaniasis is increasingly reported among travellers. Leishmania species
vary in sensitivity to available therapies. Fast and reliable molecular techniques have made …

Epidemiology of Disappearing Plasmodium vivax Malaria: A Case Study in Rural Amazonia

S Barbosa, AB Gozze, NF Lima, CL Batista… - PLOS neglected …, 2014 - journals.plos.org
Background New frontier settlements across the Amazon Basin pose a major challenge for
malaria elimination in Brazil. Here we describe the epidemiology of malaria during the early …

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

S Patterson, S Wyllie, S Norval, L Stojanovski… - Elife, 2016 - elifesciences.org
There is an urgent requirement for safe, oral and cost-effective drugs for the treatment of
visceral leishmaniasis (VL). We report that delamanid (OPC-67683), an approved drug for …