Obesity and ageing place a tremendous strain on the global healthcare system. Age-related
sarcopenia is characterized by decreased muscular strength, decreased muscle quantity …

One of the most striking adaptations to exercise is the skeletal muscle hypertrophy that
occurs in response to resistance exercise. A large body of work shows that a mammalian …

Over the past century, hydrogels have emerged as effective materials for an immense variety
of applications. The unique network structure of hydrogels enables very high levels of …

Wnt/β-catenin signaling plays a key role in the pathogenesis of colon and other cancers;
emerging evidence indicates that oncogenic β-catenin regulates several biological …

Injectable hydrogels are becoming increasingly important in the fields of tissue engineering
and drug delivery due to their tunable properties, controllable degradation, high water …

YAP1 is a transcriptional co-activator whose activity is controlled by the Hippo signaling
pathway. In addition to important functions in normal tissue homeostasis and regeneration …

THE NIMA kinase is essential for progression through mitosis in Aspergillus nidulans 1–6,
and there is evidence for a similar pathway in other eukaryotic cells5–8. Here we describe …

The human rotamase or peptidyl-prolyl cis-trans isomerase Pin1 is a conserved mitotic
regulator essential for the G2/M transition of the eukaryotic cell cycle. We report the 1.35 Å …

The amiloride‐sensitive epithelial sodium channel (ENaC) plays a major role in sodium
transport in kidney and other epithelia, and in regulating blood pressure. The channel is …

The Hippo pathway restricts the activity of transcriptional co-activators TAZ and YAP by
phosphorylating them for cytoplasmic sequestration or degradation. In this report, we …