Regulation and different functions of the animal microRNA‐induced silencing complex

PM Frédérick, MJ Simard - Wiley Interdisciplinary Reviews …, 2022 - Wiley Online Library
Among the different types of small RNAs, microRNAs (miRNAs) are key players in
controlling gene expression at the mRNA level. To be active, they must associate with an …

Cooperation and competition by RNA-binding proteins in cancer

S Nag, B Goswami, SD Mandal, PS Ray - Seminars in Cancer Biology, 2022 - Elsevier
Post-transcriptional regulation of gene expression plays a major role in determining the
cellular proteome in health and disease. Post-transcriptional control mechanisms are …

PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson's disease

B Cao, X Chen, Y Li, T Zhou, N Chen, Y Guo… - npj Parkinson's …, 2024 - nature.com
TFE3 and TFEB, as the master regulators of lysosome biogenesis and autophagy, are well
characterized to enhance the synaptic protein α-synuclein degradation in protecting against …

RNA-binding proteins: Underestimated contributors in tumorigenesis

Y Zhao, C Mir, Y Garcia-Mayea, R Paciucci… - Seminars in Cancer …, 2022 - Elsevier
Abstract mRNA export, translation, splicing, cleavage or capping determine mRNA stability,
which represents one of the primary aspects regulating gene expression and function. RNA …

PTBP1 knockdown impairs autophagy flux and inhibits gastric cancer progression through TXNIP-mediated oxidative stress

S Wang, X Wang, C Qin, C Liang, W Li, A Ran… - Cellular & Molecular …, 2024 - Springer
Background Gastric cancer (GC) is a prevalent malignant tumor, and the RNA-binding
protein polypyrimidine tract-binding protein 1 (PTBP1) has been identified as a crucial factor …

The RNA-binding protein HuR is integral to the function of nociceptors in mice and humans

N Kunder, JB de la Peña, TF Lou, R Chase… - Journal of …, 2022 - Soc Neuroscience
HuR is an RNA-binding protein implicated in RNA processing, stability, and translation.
Previously, we examined protein synthesis in dorsal root ganglion (DRG) neurons treated …

MicroRNAs, tristetraprolin Family members and HuR: a complex interplay controlling cancer-related processes

C Sobolewski, L Dubuquoy, N Legrand - Cancers, 2022 - mdpi.com
Simple Summary AU-rich Element Binding Proteins (AUBPs) represent important post-
transcriptional regulators of gene expression by regulating mRNA decay and/or translation …

p53 and HuR combinatorially control the biphasic dynamics of microRNA-125b in response to genotoxic stress

B Goswami, D Ahuja, D Pastré, PS Ray - Communications Biology, 2023 - nature.com
Post-transcriptional regulation of p53, by the microRNA miR-125b and the RNA-binding
protein HuR, controls p53 expression under genotoxic stress. p53 mRNA translation is …

Post-transcriptional Control of mRNA metabolism and protein secretion: the third level of regulation within the NF-κB system

J Priester, J Dreute, M Kracht, ML Schmitz - Biomedicines, 2022 - mdpi.com
Simple Summary Gene expression regulated by the NF-κB transcription factor pathway is a
multi-step process that finally results in the synthesis of proteins, many of which are …

Fates and functions of RNA‐binding proteins under stress

B Goswami, S Nag, PS Ray - Wiley Interdisciplinary Reviews …, 2024 - Wiley Online Library
Exposure to stress activates a well‐orchestrated set of changes in gene expression
programs that allow the cell to cope with and adapt to the stress, or undergo programmed …