The kidney is innervated with efferent sympathetic nerve fibers that directly contact the
vasculature, the renal tubules, and the juxtaglomerular granular cells. Via specific …

Background: The paraventricular nucleus of the hypothalamus (PVN) has emerged as one
of the most important autonomic control centers in the brain, with neurons playing essential …

This review describes and summarizes the role of neuronal nitric oxide synthase (nNOS) on
the central nervous system, particularly on brain regions such as the ventrolateral medulla …

Peripheral arterial disease (PAD) is a common vascular disease that reduces blood flow
capacity to the legs of patients. PAD leads to exercise intolerance that can progress in …

Background Cardiovascular diseases, including heart failure, are the most common cause of
death globally. Recent studies support a high degree of comorbidity between heart failure …

Heart failure (HF) is a complex clinical syndrome affecting roughly 26 million people
worldwide. Increased sympathetic drive is a hallmark of HF and is associated with disease …

Elevated sympathetic nerve activity, strongly associated with cardiovascular disease, is
partly generated from the presympathetic neurons of the paraventricular nucleus of the …

Our previous work indicated that the subfornical organ (SFO) is an important brain sensor of
blood-borne proinflammatory cytokines, mediating their central effects on autonomic and …

This article provides an overview of the structure and function of substance P signalling
system and its involvement in the cardiovascular regulation. Substance P is an …

Heart and kidney interactions are fascinating, in the sense that failure of the one organ
strongly affects the function of the other. In this review paper, we analyze how principal …