Assessment of enzyme inhibition: a review with examples from the development of monoamine oxidase and cholinesterase inhibitory drugs

RR Ramsay, KF Tipton - Molecules, 2017 - mdpi.com
The actions of many drugs involve enzyme inhibition. This is exemplified by the inhibitors of
monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several …

Isolation and characterization of bioactive compounds from plant resources: the role of analysis in the ethnopharmacological approach

G Brusotti, I Cesari, A Dentamaro… - … of pharmaceutical and …, 2014 - Elsevier
The phytochemical research based on ethnopharmacology is considered an effective
approach in the discovery of novel chemicals entities with potential as drug leads …

Eco-friendly approach for ZnO nanoparticles synthesis and evaluation of its possible antimicrobial, larvicidal and photocatalytic applications

C Ragavendran, C Kamaraj, K Jothimani… - Sustainable Materials …, 2023 - Elsevier
The synthesis of nanoparticles (NPs) from plants is a viable eco-friendly approach with
applications in different sectors. Thus, we aim to synthesize and characterize zinc oxide NPs …

The Presence of Microplastics in Water, Sediment, and Milkfish (Chanos chanos) at the Downstream Area of Citarum River, Indonesia

E Sembiring, AA Fareza, V Suendo, M Reza - Water, Air, & Soil Pollution, 2020 - Springer
Citarum River is the largest natural stream in West Java, Indonesia, flowing across an area
of 6614 km 2. About 3000 industries discharge their wastewater into the stream, affecting …

[HTML][HTML] Phytochemical profiling, in vitro biological activities, and in-silico molecular docking studies of Typha domingensis

R Dilshad, S Ahmad, HY Aati, JH Al-qahtani… - Arabian Journal of …, 2022 - Elsevier
A comparative study between methanolic extract and n-hexane fraction of Typha
domingensis (Typhaceae) was conducted for the evaluation of phytochemical potential, in …

High‐throughput label‐free enzymatic assays using desorption electrospray‐ionization mass spectrometry

NM Morato, DT Holden, RG Cooks - Angewandte Chemie, 2020 - Wiley Online Library
High‐throughput (HT) enzymatic assays, which typically rely on labeled compounds and
plate readers, are important for drug discovery. Mass spectrometry (MS) provides an …

Phoresis and enhanced diffusion compete in enzyme chemotaxis

J Agudo-Canalejo, P Illien, R Golestanian - Nano letters, 2018 - ACS Publications
Chemotaxis of enzymes in response to gradients in the concentration of their substrate has
been widely reported in recent experiments, but a basic understanding of the process is still …

Monitoring acetylcholinesterase level changes under oxidative stress through ESIPT-ICT-based near-infrared fluorescent probe

X Wei, T Zhu, Y Ma, J Sun, G Zheng, T Ma… - Sensors and Actuators B …, 2023 - Elsevier
Oxidative stress plays an important role in pathology, and contributes to a variety of
diseases, including inflammation, neurodegenerative diseases, and cancer. Research …

The multiple biological roles of the cholinesterases

I Silman - Progress in biophysics and molecular biology, 2021 - Elsevier
It is tacitly assumed that the biological role of acetylcholinesterase is termination of synaptic
transmission at cholinergic synapses. However, together with its structural homolog …

Automated high-throughput system combining small-scale synthesis with bioassays and reaction screening

NM Morato, MPT Le, DT Holden… - SLAS …, 2021 - journals.sagepub.com
The Purdue Make It system is a unique automated platform capable of small-scale in situ
synthesis, screening small-molecule reactions, and performing direct label-free bioassays …