In view of the advancement in the understanding about the most diverse types of cancer and
consequently a relentless search for a cure and increased survival rates of cancer patients …

Simple Summary Oncolytic Herpes simplex virus-1 (HSV-1) offers the dual potential of both
lytic tumor-specific cell killing and inducing anti-tumor immune responses. The HSV-1 …

ABSTRACT Herpes simplex virus 1 (HSV-1) causes a chronic, lifelong infection in> 60% of
adults. Multiple recent vaccine trials have failed, with viral diversity likely contributing to …

Human herpes simplex virus 1 (HSV-1), a life-long infection spread by oral contact, infects a
majority of adults globally. Phylogeographic clustering of sampled diversity into European …

Here, we present a transformational approach to genome engineering of herpes simplex
virus type 1 (HSV-1), which has a large DNA genome, using synthetic genomics tools. We …

Studies of herpes simplex virus (HSV) infections of humans are limited by the use of rodent
models such as mice, rabbits, and guinea pigs. Tree shrews (Tupaia belangeri chinensis) …

Increasing attention has focused on the contributions of persistent microbial infections with
the manifestation of disease later in life, including neurodegenerative conditions such as …

Periodic reactivation of herpes simplex virus type 1 (HSV-1) triggers immune responses that
result in corneal scarring (CS), known as herpes stromal keratitis (HSK). Despite …

Human herpesvirus type 1 (HHV-1) has a large double-stranded DNA genome of
approximately 152 kbp that is structurally complex and GC-rich. This makes the assembly of …

Whether complement dysregulation directly contributes to the pathogenesis of peripheral
nervous system diseases, including sensory neuropathies, is unclear. We addressed this …