Posttranslational modifications can cause profound changes in protein function. Typically,
these modifications are reversible, and thus provide a biochemical on-off switch. In contrast …

Collagens and proteins with collagen-like domains form large superfamilies in various
species, and the numbers of known family members are increasing constantly. Vertebrates …

The collagen prolyl 4-hydroxylases (P4Hs), enzymes residing within the endoplasmic
reticulum, have a central role in the biosynthesis of collagens. In addition, cytoplasmic P4Hs …

The nematode cuticle is an extremely flexible and resilient exoskeleton that permits
locomotion via attachment to muscle, confers environmental protection and allows growth by …

Apical extracellular matrices (aECMs) coat the exposed surfaces of animal bodies to shape
tissues, influence social interactions, and protect against pathogens and other …

Prolyl 4-hydroxylases (P4Hs) have central roles in the synthesis of collagens and the
regulation of oxygen homeostasis. The 4-hydroxyproline residues generated by the …

All nematodes possess an external structure known as the cuticle, which is crucial for their
development and survival. This structure is composed primarily of collagen, which is …

Body shape determination represents a critical aspect of morphogenesis. In the course of
investigating body shape regulation in Drosophila, we have identified a dominant mutation …

The integral role that collagens play in the morphogenesis of the nematode exoskeleton or
cuticle makes them a useful marker in the examination of the collagen synthesizing …

Collagen prolyl 4-hydroxylases (C-P4Hs) catalyze the formation of 4-hydroxyproline by the
hydroxylation of-X-Pro-Gly-triplets. The vertebrate enzymes are α 2 β 2 tetramers, the β …