The axon initial segment is a highly specialized neuronal compartment, identified almost 50
years ago by the pioneers of electron microscopy. Located in the first 50 μm of the axon, it …

Since an intact membrane is required for normal cellular homeostasis, membrane repair is
essential for cell survival. Human genetic studies, combined with the development of novel …

The axon initial segment (AIS) is a highly specialized neuronal compartment that plays a key
role in neuronal development and excitability. It concentrates multiple membrane proteins …

De novo mutations are a frequent cause of disorders related to brain development. We
report the results from the screening of two patients diagnosed with intellectual disability (ID) …

The axon initial segment (AIS) is a compartment that serves as a molecular barrier to
achieve axon-dendrite differentiation. Distribution of specific proteins during early neuronal …

Alpha‐solenoids are a significant and diverse subset of structured tandem repeat proteins
(STRPs) that are important in various domains of life. This review examines their structural …

Ankyrin repeat (AR) domains are considered the most abundant repeat motif found in
eukaryotic proteins. AR domains are predominantly known to mediate specific protein …

The axonal initial segment (AIS) is the subcellular compartment required for initiation of the
action potential in neurons. Scaffolding and regulatory proteins at the AIS cluster with ion …

Recent data shows that fibroblast growth factor 14 (FGF14) binds to and controls the function
of the voltage-gated sodium (Nav) channel with phenotypic outcomes on neuronal …

Chimpanzees (Pan troglodytes) and bonobos (Pan paniscus) are the closest living relatives
of humans, but the two species show distinct behavioral and physiological differences …