Roughly one quarter of all genes code for integral membrane proteins that are inserted into
the plasma membrane of prokaryotes or the endoplasmic reticulum membrane of …

Most eukaryotic multipass membrane proteins are inserted into the membrane of the
endoplasmic reticulum. Their transmembrane domains (TMDs) are thought to be inserted co …

Abstract α-Helical integral membrane proteins comprise approximately 25% of the proteome
in all organisms. The membrane proteome is highly diverse, varying in the number …

Introduction The continuous emergence and rapid spread of multidrug-resistant bacteria
have accelerated the demand for the discovery of alternative antibiotics. Natural plants …

The ability to study bacteria at the single cell level has advanced our insights into microbial
physiology and genetics in ways not attainable by studying large populations using more …

Background Protein transporters translocate hydrophilic segments of polypeptide across
hydrophobic cell membranes. Two protein transporters are ubiquitous and date back to the …

The membrane insertase YidC, is an essential bacterial component and functions in the
folding and insertion of many membrane proteins during their biogenesis. It is a …

The c subunits of F0F1‐ATP synthase (F0c) assemble into a ring structure, following
membrane insertion that is dependent on both glycolipid MPIase and protein YidC. We …

Abstract The YidC insertase of Escherichia coli inserts membrane proteins with small
periplasmic loops (~ 20 residues). However, it has difficulty transporting loops that contain …

Over the last decade, the study of CRISPR-Cas systems has progressed from a newly
discovered bacterial defense mechanism to a diverse suite of genetic tools that have been …