Nrf2/ARE signaling directly regulates SOX9 to potentially alter age-dependent cartilage degeneration

Y Kubo, R Beckmann, A Fragoulis, C Conrads… - Antioxidants, 2022 - mdpi.com
Oxidative stress is implicated in osteoarthritis, and nuclear factor erythroid 2–related factor 2
(Nrf2)/antioxidant response element (ARE) pathway maintains redox homeostasis. We …

The role of mitochondrial reactive oxygen species in chondrocyte mechanotransduction

A Momin, S Perrotti, SD Waldman - Journal of Orthopaedic …, 2024 - Wiley Online Library
Chondrocytes are mechanosensitive cells able to sense and respond to external
mechanical stimuli through the process of mechanotransduction. Previous studies have …