A large body of experimental evidence suggests that neuroinflammation is a key
pathological event triggering and perpetuating the neurodegenerative process associated …

Huntington's disease is an inherited neurodegenerative disease described 150 years ago
by George Huntington. The genetic defect was identified in 1993 to be an expanded CAG …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

Neurodegenerative diseases can have long preclinical phases and insidious progression
patterns, but the mechanisms of disease progression are poorly understood. Because …

Huntington's disease (HD) is caused by an expansion of cytosine–adenine–guanine (CAG)
repeats in the huntingtin gene, which leads to neuronal loss in the striatum and cortex and to …

Huntington's disease (HD) is a dominantly inherited progressive neurological disease
characterized by chorea, an involuntary brief movement that tends to flow between body …

Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is
the most common inherited spinocerebellar ataxia and one of many polyglutamine …

The lysosome-mediated degradation pathway known as macroautophagy is the most
versatile means through which cells can eliminate and recycle unwanted materials. Through …

Microtubule-based transport is essential for neuronal function because of the large
distances that must be traveled by various building blocks and cellular materials. Recent …

Protein misfolding, whether caused by aging, environmental factors, or genetic mutations, is
a common basis for neurodegenerative diseases. The misfolding of proteins with abnormally …