Personalized cancer vaccines (PCVs) are reinvigorating vaccine strategies in cancer
immunotherapy. In contrast to adoptive T-cell therapy and checkpoint blockade, the PCV …

Activation of the cyclic guanosine monophosphate-adenosine monophosphate synthase
(cGAS)-stimulator of interferon genes (STING) pathway has great potential to promote …

Stimulator of interferon genes (STING) plays a crucial role in human innate immune system,
which is gradually concerned following the emerging immunotherapy. Activated STING …

Despite great progress, the current cancer treatments often have obvious toxicity and side
effects. and a poor prognosis (some patients). One of the reasons for the poor prognosis is …

Immunoengineering is a rapidly evolving field that has been driving innovations in
manipulating immune system for new treatment tools and methods. The need for materials …

Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose a significant global …

Objectives This study aimed to identify novel targets in the carcinogenesis, therapy and
prognosis of osteosarcoma from genomic level, together with screening ideal lead …

The stimulator of interferon genes (STING) is an adaptor protein involved in the activation of
IFN-β and many other genes associated with the immune response activation in vertebrates …

Traf2 and Nck-interacting kinase (TNIK) is the downstream molecule of Wnt/β-catenin signal
pathway. As the activation kinase of β-catenin/T-cell factor 4 transcription complex, it can …

Object: This study was designed to screen ideal lead compounds and drug candidates with
an inhibitory effect on PARP from the drug library (ZINC database). Results: Two effective …