Endothelial dysfunction and preeclampsia: role of oxidative stress

LC Sánchez-Aranguren, CE Prada… - Frontiers in …, 2014 - frontiersin.org
Preeclampsia (PE) is an often fatal pathology characterized by hypertension and proteinuria
at the 20th week of gestation that affects 5–10% of the pregnancies. The problem is …

Obesity and preeclampsia: common pathophysiological mechanisms

P Lopez-Jaramillo, J Barajas… - Frontiers in …, 2018 - frontiersin.org
Preeclampsia is a disorder specific of the human being that appears after 20 weeks of
pregnancy, characterized by new onset of hypertension and proteinuria. Abnormal …

The L-arginine paradox: importance of the L-arginine/asymmetrical dimethylarginine ratio

SM Bode-Böger, F Scalera, LJ Ignarro - Pharmacology & therapeutics, 2007 - Elsevier
Cardiovascular diseases (CVD) are still the most frequent cause of death in Western
Europe. Pathophysiological experiments revealed in the last years that the vascular …

Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems

F Palm, ML Onozato, Z Luo… - American Journal of …, 2007 - journals.physiology.org
Asymmetric (NG, NG)-dimethylarginine (ADMA) inhibits nitric oxide (NO) synthases (NOS).
ADMA is a risk factor for endothelial dysfunction, cardiovascular mortality, and progression …

Asymmetric dimethylarginine (ADMA): a novel risk marker in cardiovascular medicine and beyond

RH Böger - Annals of medicine, 2006 - Taylor & Francis
There is abundant evidence that the endothelium plays a crucial role in the maintenance of
vascular tone and structure. One of the major endothelium‐derived vasoactive mediators is …

Clinical presentation of preeclampsia and the diagnostic value of proteins and their methylation products as biomarkers in pregnant women with preeclampsia and …

M Portelli, B Baron - Journal of pregnancy, 2018 - Wiley Online Library
Preeclampsia (PE) is a disorder which affects 1‐10% of pregnant women worldwide. It is
characterised by hypertension and proteinuria in the later stages of gestation and can lead …

The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis

J Leiper, M Nandi - Nature Reviews Drug Discovery, 2011 - nature.com
Asymmetric dimethylarginine (ADMA)—a naturally occurring amino acid that is a product of
protein breakdown—is released into the cytoplasm following the post-translational …

High-throughput liquid chromatographic-tandem mass spectrometric determination of arginine and dimethylated arginine derivatives in human and mouse plasma

E Schwedhelm, R Maas, J Tan-Andresen… - … of Chromatography B, 2007 - Elsevier
The balance between nitric oxide (NO) and vasoconstrictors like endothelin is essential for
vascular tone and endothelial function. l-Arginine is converted to NO and l-citrulline by NO …

Raised C-reactive protein and impaired flow-mediated vasodilation precede the development of preeclampsia

RG Garciéa, J Celedón… - American journal of …, 2007 - academic.oup.com
Background: The aim of this study was to investigate whether impaired flow mediated
vasodilation precedes the clinical manifestations of preeclampsia and whether is associated …

[HTML][HTML] Desenlaces materno-fetales de los embarazos con trastornos hipertensivos: Un estudio transversal.

MA Mendoza-Cáceres, LC Moreno-Pedraza… - Revista chilena de …, 2020 - SciELO Chile
Introducción y objetivo: Los trastornos hipertensivos asociados al embarazo son
considerados un problema de salud pública. Se busca describir las características clínicas y …