Myeloid-derived suppressor cells (MDSCs) constitute a vast population of immature myeloid
cells implicated in various conditions. Most notably, their role in cancer is of great …

Interferon (IFN)-λ, a type III interferon (IFN), is a member of a new family of pleotropic
cytokines that share high similarity with classical IFNs α and β (IFN-α/β), type I IFNs. IFN-λ …

The etiology of ulcerative colitis is poorly understood and is likely to involve perturbation of
the complex interactions between the mucosal immune system and the commensal bacteria …

Non-small cell lung cancer (NSCLC) is the most frequent type of lung cancer accounting up
to 80–85% of all lung cancer (LC) cases. Gemcitabine (Gem), a pyrimidine nucleoside …

Background IFN-λ has been shown to have a dual function in cancer, with its tumor-
suppressive roles being well-established. However, the potential existence of a negative …

The overexpression of cyclooxygenase-2 (COX-2) has been documented in many types of
cancer occurring in humans and animals. Increasing evidences have shown that the …

Metastatic colorectal cancer (CRC) is still in need of effective treatments. This study applies
a holistic approach to propose new targets for treatment of primary and liver metastatic CRC …

Tumor-infiltrating immune cells can impact tumor growth and progression. The inhibitory
CD200 receptor (CD200R) suppresses the activation of myeloid cells and lack of this …

Sustained angiogenesis stands as a hallmark of cancer. The intricate vascular tumor
microenvironment fuels cancer progression and metastasis, fosters therapy resistance, and …

In cancer cells exposed to extracellular pressure or shear stress, AKT1-FAK interaction
drives focal adhesion kinase (FAK) phosphorylation, leading to force-activated cancer cell …