Advancement in leishmaniasis diagnosis and therapeutics: An update

D Kumari, S Perveen, R Sharma, K Singh - European Journal of …, 2021 - Elsevier
Leishmaniasis is regarded as a neglected tropical disease by World Health Organization
(WHO) and is ranked next to malaria as the deadliest protozoan disease. The primary …

Statins: a viable candidate for host-directed therapy against infectious diseases

SP Parihar, R Guler, F Brombacher - Nature Reviews Immunology, 2019 - nature.com
Statins were first identified over 40 years ago as lipid-lowering drugs and have been
remarkably effective in treating cardiovascular diseases. As research advanced, the …

Tackling drug resistance and other causes of treatment failure in leishmaniasis

GJ Wijnant, F Dumetz, L Dirkx, D Bulté… - Frontiers in Tropical …, 2022 - frontiersin.org
Leishmaniasis is a tropical infectious disease caused by the protozoan Leishmania parasite.
The disease is transmitted by female sand flies and, depending on the infecting parasite …

Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art

RL Charlton, B Rossi-Bergmann, PW Denny, PG Steel - Parasitology, 2018 - cambridge.org
Leishmaniasis is a vector-borne neglected tropical disease caused by protozoan parasites
of the genus Leishmania for which there is a paucity of effective viable non-toxic drugs …

Diabetes-associated susceptibility to tuberculosis: contribution of hyperglycemia vs. Dyslipidemia

MD Ngo, S Bartlett, K Ronacher - Microorganisms, 2021 - mdpi.com
Diabetes is a major risk factor for tuberculosis (TB). Diabetes increases the risk of the
progression from latent tuberculosis infection (LTBI) to active pulmonary TB and TB patients …

The immunomodulatory effects of statins on macrophages

A Sheridan, CPD Wheeler-Jones, MC Gage - Immuno, 2022 - mdpi.com
Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors used
worldwide to manage dyslipidaemia and thus limit the development of atherosclerotic …

Host-directed drug therapies for neglected tropical diseases caused by protozoan parasites

S Varikuti, BK Jha, G Volpedo, NM Ryan… - Frontiers in …, 2018 - frontiersin.org
The neglected tropical diseases (NTDs) caused by protozoan parasites are responsible for
significant morbidity and mortality worldwide. Current treatments using anti-parasitic drugs …

An appraisal of the scientific current situation and new perspectives in the treatment of cutaneous leishmaniasis

CAB Nieva, AG Cid, AI Romero, MF García-Bustos… - Acta Tropica, 2021 - Elsevier
Abstract Leishmaniasis is a Neglected Tropical Diseases caused by protozoan parasites of
the genus Leishmania. It is a major health problem in many tropical and subtropical regions …

Need for sustainable approaches in antileishmanial drug discovery

S Hendrickx, G Caljon, L Maes - Parasitology research, 2019 - Springer
Leishmaniasis is a neglected parasitic disease for which the current antileishmania
therapeutics are hampered by drug toxicity, high cost, need for parenteral administration …

[HTML][HTML] Statins: antimicrobial resistance breakers or makers?

HHT Ko, RR Lareu, BR Dix, JD Hughes - PeerJ, 2017 - peerj.com
Methods A literature search using keywords “statin” or “statins” combined with “minimum
inhibitory concentration”(MIC) was performed in six databases on 7th April 2017. After …