Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

Mucosal surfaces are lined by epithelial cells, which provide a complex and adaptive
module that ensures first-line defense against external toxics, irritants, antigens, and …

Epithelial-to-mesenchymal transition (EMT) is a reversible process, in which epithelial cells
lose their epithelial traits and acquire a mesenchymal phenotype. This transformation has …

Cystic fibrosis transmembrane conductance regulator (CFTR) is a protein that plays a crucial
role in various human organs, including the respiratory and digestive systems. Dysfunctional …

Renal interstitial fibrosis is the pathological basis of end-stage renal disease, in which the
heterogeneity of macrophages in renal microenvironment plays an important role. However …

The abnormal lipid and glucose metabolisms are linked to the metabolic disorders,
tumorigenesis, and fibrotic diseases, which attracts the increasing attention to find out the …

SLC26A9, a constitutively active Cl− transporter, has gained interest over the past years as a
relevant disease modifier in several respiratory disorders including Cystic Fibrosis (CF) …

The multi-organ disease cystic fibrosis (CF) is caused by mutations in the gene encoding the
CF transmembrane conductance regulator (CFTR) protein, a cAMP regulated chloride (Cl−) …

Airway remodeling caused by asthma is characterized by structural changes of subepithelial
fibrosis, goblet cell metaplasia, submucosal gland hyperplasia, smooth muscle cell …

Background The phenotypic heterogeneity observed in Cystic Fibrosis (CF) patients
suggests the involvement of other genes, besides CFTR. Here, we combined transcriptome …