We summarize the currently available information regarding the state of ionization and
tautomerization of the 4′‐aminopyrimidine ring of the thiamine diphosphate on enzymes …

Enzymes that use thiamin diphosphate (ThDP), the biologically active derivative of vitamin
B1, as a cofactor play important roles in cellular metabolism in all domains of life. The …

Carbon dioxide (CO2) is an important carbon feedstock for a future green economy. This
requires the development of efficient strategies for its conversion into multicarbon …

One of the most abundant sources of organic carbon in the ocean is glycolate, the secretion
of which by marine phytoplankton results in an estimated annual flux of one petagram of …

A novel biocatalytic system for the synthesis of industrially relevant C2 chemicals (eg,
ethylene glycol (3)) from formaldehyde (1) was established. The biocatalytic system …

Ethylene glycol (EG) is a promising next generation feedstock for bioprocesses. It is a key
component of the ubiquitous plastic polyethylene terephthalate (PET) and other polyester …

Acetohydroxyacid synthase, a thiamine diphosphate-dependent enzyme, can condense
either two pyruvate molecules to form acetolactate for synthesizing L-valine and L-leucine or …

A number of carboligases, which catalyze condensation of C1-and/or C2-aldehydes into
multi-carbon products, have been reported. However, their catalytic activities and/or …

This review is focused on three types of enzymes decarboxylating very different
substrates:(1) thiamin diphosphate (ThDP)-dependent enzymes reacting with 2-oxo …

Abstract The natural antivitamin 2′-methoxy-thiamine (MTh) is implicated in the
suppression of microbial growth. However, its mode of action and enzyme-selective …