Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

Alzheimer's disease (AD) is the most common cause of dementia worldwide. The etiology is
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …

Recent findings suggest that tau oligomers, which form before neurofibrillary tangles (NFTs),
are the true neurotoxic tau entities in neurodegenerative tauopathies, including Alzheimer's …

In general, proteins can only execute their various biological functions when they are
appropriately folded. Their amino acid sequence encodes the relevant information required …

Alzheimer's disease (AD) is the most common cause of memory impairment and dementia in
the elderly. AD is pathologically characterized by extracellular deposits of beta-amyloid (Aβ) …

It is well-established that inflammation plays an important role in Alzheimer's disease (AD)
and frontotemporal lobar dementia (FTLD). Inflammation and synapse loss occur in disease …

Several studies have proposed that fibrillary aggregates of tau and other amyloidogenic
proteins are neurotoxic and result in numerous neurodegenerative diseases. However …

Recent data indicate that Tau immunotherapy may be relevant for interfering with
neurofibrillary degeneration in Alzheimer disease and related disorders referred to as …

Neuroinflammation is a process related to the onset of several neurodegenerative disorders,
including Alzheimer's disease (AD). Increasing sets of evidence support the major role of …

In Alzheimer's disease (AD), the pathological accumulation of tau appears to be a
downstream effect of amyloid β protein (Aβ). However, the relationship between these two …