MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

The NF-κB family of transcription factors has an essential role in inflammation and innate
immunity. Furthermore, NF-κB is increasingly recognized as a crucial player in many steps of …

The nuclear factor kB (NF-kB) comprises a family of transcription factors involved in the
regulation of a wide variety of biological responses. NF-kB plays a well-known function in …

A steadily growing number of studies have shown that microRNAs have key roles in the
regulation of cellular processes and that their dysregulation is essential to keep the …

Abstract c-myc, N-myc and L-myc are the three members of the myc oncoprotein family
whose role in the pathogenesis of many human neoplastic diseases has received wide …

WNTs and their downstream effectors regulate proliferation, death, and migration and cell
fate decision. Deregulation of WNT signaling is associated with various cancers including …

Although lymphoma is a very heterogeneous group of biologically complex malignancies,
tumor cells across all B cell lymphoma subtypes share a set of underlying traits that promote …

Rel/NF-κB transcription factors are key regulators of immune, inflammatory and acute phase
responses and are also implicated in the control of cell proliferation and apoptosis …

The amplification at 13q31-q32 has been reported in not only hematopoietic malignancies
but also in other solid tumors. We identified previously frequent amplification of …

Apoptosis is a highly regulated process of cell deletion and plays a fundamental role in the
maintenance of tissue homeostasis in the adult organism. Numerous studies in recent years …