[HTML][HTML] Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging

Z Turi, M Lacey, M Mistrik, P Moudry - Aging (Albany NY), 2019 - ncbi.nlm.nih.gov
The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …

New perspectives of physiological and pathological functions of nucleolin (NCL)

W Jia, Z Yao, J Zhao, Q Guan, L Gao - Life sciences, 2017 - Elsevier
Nucleolin (NCL) is a multifunctional protein that mainly localized in the nucleolus, it is also
found in the nucleoplasm, cytoplasm and cell membrane. The three main structural domains …

RNA seeds higher-order assembly of FUS protein

JC Schwartz, X Wang, ER Podell, TR Cech - Cell reports, 2013 - cell.com
The abundant nuclear RNA binding protein FUS binds the C-terminal domain (CTD) of RNA
polymerase II in an RNA-dependent manner, affecting Ser2 phosphorylation and …

Structure and functions of nucleolin

H Ginisty, H Sicard, B Roger… - Journal of cell …, 1999 - journals.biologists.com
Nucleolin is an abundant protein of the nucleolus. Nucleolar proteins structurally related to
nucleolin are found in organisms ranging from yeast to plants and mammals. The …

The new (dis) order in RNA regulation

AI Järvelin, M Noerenberg, I Davis… - Cell Communication and …, 2016 - Springer
RNA-binding proteins play a key role in the regulation of all aspects of RNA metabolism,
from the synthesis of RNA to its decay. Protein-RNA interactions have been thought to be …

The roles of nucleolin subcellular localization in cancer

CM Berger, X Gaume, P Bouvet - Biochimie, 2015 - Elsevier
Nucleolin (NCL) is one of the most abundant non ribosomal protein of the nucleolus where it
plays a central role in polymerase I transcription. NCL is also found outside of the nucleolus …

Ribosome Synthesis in Saccharomyces cerevisiae

J Venema, D Tollervey - Annual review of genetics, 1999 - annualreviews.org
▪ Abstract The synthesis of ribosomes is one of the major metabolic pathways in all cells. In
addition to around 75 individual ribosomal proteins and 4 ribosomal RNAs, synthesis of a …

RNA-binding protein nucleolin in disease

K Abdelmohsen, M Gorospe - RNA biology, 2012 - Taylor & Francis
Nucleolin is a multifunctional protein localized primarily in the nucleolus, but also found in
the nucleoplasm, cytoplasm and cell membrane. It is involved in several aspects of DNA …

Nucleolin: The most abundant multifunctional phosphoprotein of nucleolus

MM Tajrishi, R Tuteja, N Tuteja - Communicative & integrative …, 2011 - Taylor & Francis
Nucleolin is multifunctional phosphoprotein ubiquitously distributed in the nucleolus,
nucleus and cytoplasm of the cell. Nucleolin has a bipartite nuclear localization signal …

Molecular dissection of nucleolin's role in growth and cell proliferation: new insights

M Srivastava, HB Pollard - The FASEB Journal, 1999 - Wiley Online Library
Cells require optimum protein synthetic activity in order to support cell proliferation, maintain
homeostatic and metabolic integrity, and repair damage. Since growth depends on protein …