Versatile peptide-based nanosystems for photodynamic therapy

Q Li, R Ming, L Huang, R Zhang - Pharmaceutics, 2024 - mdpi.com
Photodynamic therapy (PDT) has become an important therapeutic strategy because it is
highly controllable, effective, and does not cause drug resistance. Moreover, precise …

Revolutionizing anticancer treatment: Ruthenium-based nanoplatforms pave new paths

D Karati, S Meur, S Mukherjee, S Roy - Coordination Chemistry Reviews, 2024 - Elsevier
Cancer ranks among the top causes of mortality on a global scale. The only treatments
available for cancer nowadays are surgery, radiation therapy, and the use of cytotoxic …

A nanoencapsulated Ir (III)-phthalocyanine conjugate as a promising photodynamic therapy anticancer agent

J Bonelli, E Ortega-Forte, G Vigueras… - … Applied Materials & …, 2024 - ACS Publications
Despite the potential of photodynamic therapy (PDT) in cancer treatment, the development
of efficient and photostable photosensitizing molecules that operate at long wavelengths of …

Increasing the π-expansive ligands in ruthenium (II) polypyridyl complexes: synthesis, characterization, and biological evaluation for photodynamic therapy …

MD Pozza, P Mesdom, A Abdullrahman… - Inorganic …, 2023 - ACS Publications
Lack of selectivity is one of the main issues with currently used chemotherapies, causing
damage not only to altered cells but also to healthy cells. Over the last decades …

Red‐Light Activation of a Microtubule Polymerization Inhibitor via Amide Functionalization of the Ruthenium Photocage

L Bretin, Y Husiev, V Ramu, L Zhang… - Angewandte Chemie …, 2024 - Wiley Online Library
Photoactivated chemotherapy (PACT) is a promising cancer treatment modality that kills
cancer cells via photochemical uncaging of a cytotoxic drug. Most ruthenium‐based …

Ru (II) Phenanthroline-Based Oligothienyl Complexes as Phototherapy Agents

HD Cole, A Vali, JA Roque III, G Shi, G Kaur… - Inorganic …, 2023 - ACS Publications
Ru (II) polypyridyl complexes have gained widespread attention as photosensitizers for
photodynamic therapy (PDT). Herein, we systematically investigate a series of the type [Ru …

Nature-inspired photocatalytic azo bond cleavage with red light

Z Zhao, J Li, W Yuan, D Cheng, S Ma… - Journal of the …, 2023 - ACS Publications
The emerging field of photoredox catalysis in mammalian cells enables spatiotemporal
regulation of a wealth of biological processes. However, the selective cleavage of stable …

Recent advances for enhanced photodynamic therapy: from new mechanisms to innovative strategies

X Wang, J Peng, C Meng, F Feng - Chemical Science, 2024 - pubs.rsc.org
Photodynamic therapy (PDT) has been developed as a potential cancer treatment approach
owing to its non-invasiveness, spatiotemporal control and limited side effects. Currently …

Oxygen-dependent interactions between the ruthenium cage and the photoreleased inhibitor in NAMPT-targeted photoactivated chemotherapy

S Abyar, L Huang, Y Husiev, L Bretin… - Journal of Medicinal …, 2024 - ACS Publications
Photoactivated chemotherapy agents form a new branch of physically targeted anticancer
agents with potentially lower systemic side effects for patients. On the other hand, limited …

Exploiting the Potential of Iridium(III) bis-Nitrone Complexes as Phosphorogenic Bifunctional Reagents for Phototheranostics

ECL Mak, Z Chen, LCC Lee, PKK Leung… - Journal of the …, 2024 - ACS Publications
Cross-linking strategies have found wide applications in chemical biology, enabling the
labeling of biomolecules and monitoring of protein–protein interactions. Nitrone exhibits …