Our previous studies have clearly shown that the angiogenic enzymes, matrix
metalloproteinase (MMP)‐2/9, are directly involved in human hepatic tumorigenesis and …

Dysregulation of pleiotropic growth factors, receptors and their downstream signaling
pathway components represent a central protumorigenic principle in human …

ABSTRACT Hepatitis B virus (HBV) X protein (HBx) has been shown to be essential for the
development of hepatocellular carcinoma (HCC). Recently, we have found that HBx causes …

Hepatocyte growth factor plays multiple roles in cancer, by acting as a motility and invasion
stimulating factor, promoting metastasis and tumour growth. Furthermore, it acts as a …

Oxidative stress imposed by reactive oxygen species (ROS) plays a crucial role in the
pathophysiology associated with neoplasia, atherosclerosis, and neurodegenerative …

Vanillin, a food flavoring agent, has been reported to show anti-mutagenic activity and to
inhibit chemical carcinogenesis. In this study, we examined the effect of vanillin on the …

Hepatocellular carcinoma (HCC) is the third deadliest and fifth most common human cancer
worldwide. Hepatitis C virus (HCV) and hepatitis B virus (HBV) infections along with alcohol …

Advanced hepatocellular carcinoma (HCC) is an important cause of cancer mortality.
Epithelial-mesenchymal transition (EMT) has been shown to be an important biological …

3-Methyl-1, 6, 8-trihydroxyanthraquinone (emodin) is an active component from the rhizome
of Rheum palmatum, a widely used traditional Chinese herb. In this study, we found that …

Recent epidemiological studies indicated risk reductions in ovarian cancer with
consumption of acetaminophen or nonsteroid anti-inflammatory drugs. Until now, there is not …