The necessity of being “first on the market” paired with the need to cut production costs
highlights the need for strategies and techniques allowing a fast process development while …

Over the last decade, the term process intensification (PI) has been applied almost
exclusively to large scale chemical processes, but hardly to aspects of biopharmaceutical …

This publication details the isolation of proteins from biological materials, techniques for
solid-liquid separation, concentration, crystallization, chromatography, scale-up, process …

Enzymes are the catalysts responsible for cell metabolism. Cells from different sources have
been, are, and will continue to be the main source of enzymes. Enzymes can be produced …

We investigate protein purification operations conducted by biomanufacturers and
pharmaceutical companies as part of their research and development efforts. Purification of …

This work addresses the integrated optimization of upstream and downstream processing
strategies of a monoclonal antibody (mAb) under uncertainty. In the upstream processing …

This work addresses the multi-objective optimisation of manufacturing strategies of
monoclonal antibodies under uncertainty. The chromatography sequencing and column …

The strategies employed in chromatography steps play a key role in downstream processes
for monoclonal antibody (mAb) manufacture. This work addresses the integrated …

Recombinant DNA-derived proteins and, in particular, human pituitary hormones, are
increasingly used for research, diagnostic and therapeutic purposes. This trend has …

Highlights•Integrated modelling of bioprocess engineering is valuable for many
reasons.•Data-based and mechanistic models of multi-step processes are …