Structural, molecular, and functional alterations of the blood-brain barrier during epileptogenesis and epilepsy: a cause, consequence, or both?

W Löscher, A Friedman - International journal of molecular sciences, 2020 - mdpi.com
The blood-brain barrier (BBB) is a dynamic, highly selective barrier primarily formed by
endothelial cells connected by tight junctions that separate the circulating blood from the …

Astrocytes as guardians of neuronal excitability: mechanisms underlying epileptogenesis

QP Verhoog, L Holtman, E Aronica… - Frontiers in …, 2020 - frontiersin.org
Astrocytes are key homeostatic regulators in the central nervous system and play important
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …

Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain

Y Anraku, H Kuwahara, Y Fukusato… - Nature …, 2017 - nature.com
Recently, nanocarriers that transport bioactive substances to a target site in the body have
attracted considerable attention and undergone rapid progression in terms of the state of the …

Microglia-mediated inflammation and neurodegenerative disease

L Xu, D He, Y Bai - Molecular Neurobiology, 2016 - Springer
Microglia are the main effectors in the inflammatory process of the central nervous system.
As the first line of defense, microglia play an important role in the inflammatory reaction …

Development of epilepsy after ischaemic stroke

A Pitkänen, R Roivainen, K Lukasiuk - The Lancet Neurology, 2016 - thelancet.com
For about 30% of patients with epilepsy the cause is unknown. Even in patients with a
known risk factor for epilepsy, such as ischaemic stroke, only a subpopulation of patients …

Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management

C Rawat, S Kukal, UR Dahiya, R Kukreti - Journal of neuroinflammation, 2019 - Springer
Epilepsy, a common multifactorial neurological disease, affects about 69 million people
worldwide constituting nearly 1% of the world population. Despite decades of extensive …

Pesticides at brain borders: Impact on the blood-brain barrier, neuroinflammation, and neurological risk trajectories

N Cresto, I Forner-Piquer, A Baig, M Chatterjee… - Chemosphere, 2023 - Elsevier
Pesticides are omnipresent, and they pose significant environmental and health risks.
Translational studies indicate that acute exposure to high pesticide levels is detrimental, and …

Stroke‐related epilepsy

AM Feyissa, TF Hasan… - European journal of …, 2019 - Wiley Online Library
Stroke is the cause of about 10% of all epilepsy and 55% of newly diagnosed seizures
among the elderly. Although recent advances in acute stroke therapy have improved …

Endothelial β-catenin signaling is required for maintaining adult blood–brain barrier integrity and central nervous system homeostasis

KA Tran, X Zhang, D Predescu, X Huang… - Circulation, 2016 - Am Heart Assoc
Background—The blood–brain barrier (BBB) formed by brain endothelial cells
interconnected by tight junctions is essential for the homeostasis of the central nervous …

Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models

PH Patra, M Barker‐Haliski, HS White, BJ Whalley… - …, 2019 - Wiley Online Library
Objective Epilepsy is a progressive neurological disease characterized by recurrent
seizures and behavioral comorbidities. We investigated the antiseizure effect of cannabidiol …