TEER measurement techniques for in vitro barrier model systems

B Srinivasan, AR Kolli, MB Esch… - Journal of …, 2015 - journals.sagepub.com
Transepithelial/transendothelial electrical resistance (TEER) is a widely accepted
quantitative technique to measure the integrity of tight junction dynamics in cell culture …

Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells—overview and perspectives

X Cao, JP Coyle, R Xiong, Y Wang, RH Heflich… - In Vitro Cellular & …, 2021 - Springer
The lung is an organ that is directly exposed to the external environment. Given the large
surface area and extensive ventilation of the lung, it is prone to exposure to airborne …

Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia

M Toots, JJ Yoon, RM Cox, M Hart, ZM Sticher… - Science translational …, 2019 - science.org
Influenza viruses constitute a major health threat and economic burden globally, frequently
exacerbated by preexisting or rapidly emerging resistance to antiviral therapeutics. To …

An inhalable hybrid biomimetic nanoplatform for sequential drug release and remodeling lung immune homeostasis in acute lung injury treatment

C Liu, L Xi, Y Liu, JCW Mak, S Mao, Z Wang, Y Zheng - ACS nano, 2023 - ACS Publications
Interactions of lung macrophages and recruited neutrophils with the lung microenvironment
continuously aggravate the dysregulation of lung inflammation in the pathogenesis of acute …

Nanomedicine in pulmonary delivery

HM Mansour, YS Rhee, X Wu - International journal of …, 2009 - Taylor & Francis
The lung is an attractive target for drug delivery due to noninvasive administration via
inhalation aerosols, avoidance of first-pass metabolism, direct delivery to the site of action …

Mucus models to evaluate the diffusion of drugs and particles

JY Lock, TL Carlson, RL Carrier - Advanced drug delivery reviews, 2018 - Elsevier
Mucus is a complex hydrogel that acts as a natural barrier to drug delivery at different
mucosal surfaces including the respiratory, gastrointestinal, and vaginal tracts. To elucidate …

[HTML][HTML] Air-liquid interface (ALI) impact on different respiratory cell cultures

S Silva, J Bicker, A Falcão, A Fortuna - European Journal of Pharmaceutics …, 2023 - Elsevier
The intranasal route has been receiving greater attention from the scientific community not
only for systemic drug delivery but also for the treatment of pulmonary and neurological …

Real‐Time Measurement of Cell Mechanics as a Clinically Relevant Readout of an In Vitro Lung Fibrosis Model Established on a Bioinspired Basement Membrane

A Doryab, MB Taskin, P Stahlhut, J Groll… - Advanced …, 2022 - Wiley Online Library
Lung fibrosis, one of the major post‐COVID complications, is a progressive and ultimately
fatal disease without a cure. Here, an organ‐and disease‐specific in vitro mini‐lung fibrosis …

Carrier interactions with the biological barriers of the lung: advanced in vitro models and challenges for pulmonary drug delivery

C de Souza Carvalho, N Daum, CM Lehr - Advanced Drug Delivery …, 2014 - Elsevier
In recent years significant progress has been made to improve particle deposition in the
lung. However, the development of strategies to overcome the air–blood lung barrier is still …

Drug transporters in the lung—do they play a role in the biopharmaceutics of inhaled drugs?

C Bosquillon - Journal of pharmaceutical sciences, 2010 - Elsevier
The role of transporters in drug absorption, distribution and elimination processes as well as
in drug–drug interactions is increasingly being recognised. Although the lungs express high …