Causative or associative: A critical review of the role of advanced glycation end-products in bone fragility

TL Willett, P Voziyan, JS Nyman - Bone, 2022 - Elsevier
The accumulation of advanced glycation end-products (AGEs) in the organic matrix of bone
with aging and chronic disease such as diabetes is thought to increase fracture risk …

Advanced glycation end products and bone–how do we measure them and how do they correlate with bone mineral density and fractures? A systematic review and …

IAG Brandt, MH Jessen, DE Rimestad, MKF Højgaard… - Bone, 2022 - Elsevier
The role of advanced glycation end products (AGEs) in bone fragility especially in diabetic
bone disease is increasingly recognized and researched. As skeletal frailty in diabetes does …

Physicochemical understanding of biomineralization by molecular vibrational spectroscopy: From mechanism to nature

H Liu, H Jiang, X Liu, X Wang - Exploration, 2023 - Wiley Online Library
The process and mechanism of biomineralization and relevant physicochemical properties
of mineral crystals are remarkably sophisticated multidisciplinary fields that include biology …

Advanced glycation end products inhibit the osteogenic differentiation potential of adipose-derived stem cells in mice through autophagy

T Fu, Q Zhu, F Lou, S Cai, S Peng, J Xiao - Cellular Signalling, 2023 - Elsevier
Background Diabetes mellitus (DM) microenvironment will accelerate the accumulation of
Advanced glycation end products (AGEs), adipose-derived stem cells (ASCs) have poor …

In Vivo Assessment of Bone Quality Without X-rays

RK Surowiec, MD Does, JS Nyman - Current Osteoporosis Reports, 2024 - Springer
Abstract Purpose of Review This review summarizes recent advances in the assessment of
bone quality using non-X-ray techniques. Recent Findings Quantitative ultrasound (QUS) …

Chemerin mediates exercise-induced improvements of bone microstructure and bone mass in diabetes or high fat diet mice

X Yu, X Pan, M Huang, X Lin, X Wang - Molecular and Cellular …, 2025 - Elsevier
To clarify the roles and mechanisms of adipokine chemerin in exercise-induced bone
improvements in type 2 diabetes mellitus (DM) mice and mice fed on high fat diet (HFD). DM …

A survey on the mechanical properties of bone

SS Barekar, SS Sarawade, N Kumar - Multimedia Tools and Applications, 2024 - Springer
The cellular component and an extracellular matrix make up the bone. Osteoblasts, bone-
lining cells, osteocytes, and osteomacs that are dormant osteoblasts trapped in the …

LDN protects bone property deterioration at different hierarchical levels in T2DM mice bone

P Shitole, A Choubey, P Mondal, R Ghosh - ACS omega, 2021 - ACS Publications
Type 2 diabetes mellitus (T2DM) commonly affects bone quality at different hierarchical
levels and leads to an increase in the risk of bone fracture. Earlier, some anti-diabetic drugs …

[PDF][PDF] Unexpected Increase in Bone Mineral Density With Rapamycin and Low-Dose Naltrexone: A Case Report of a 52-Year-Old Woman With Osteopenia

A Britton, G Harinath, S Morgan, S Zalzala, AE Britton - Cureus, 2025 - cureus.com
Osteopenia and osteoporosis are prevalent bone disorders characterized by reduced bone
mineral density (BMD), leading to an increased risk of fractures. This case report presents a …

Recent Advances in Promoting Bone Regeneration in Type 2 Diabetes Using Drug Delivery Vehicles and Vehicle‐Free Therapeutics

Y Pesaran Afsharian, M Rahimnejad… - Advanced … - Wiley Online Library
The incidence of type 2 diabetes (T2DM) increases significantly worldwide. Due to
consistent hyperglycemia, insulin resistance, and chronic inflammation, T2DM patients …