The understanding of vertebrate development has advanced considerably in recent years,
primarily due to the study of a few model organisms. The zebrafish, the newest of these …

The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and
cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the …

Inconsistent activity limits the use of CRISPR-Cas9 in zebrafish. We show supernumerary
guanine nucleotides at the 5′ ends of single guide RNAs (sgRNAs) account for diminished …

In a large-scale screen, we isolated mutants displaying a specific visible phenotype in
embryos or early larvae of the zebrafish, Danio rerio. Males were mutagenized with …

The zebrafish has become one of the most important model organisms to study biologial
processes in vivo. As a vertebrate that has many of the strengths of invertebrate model …

Bone morphogenetic protein (BMP) signals coordinate developmental patterning and have
essential physiological roles in mature organisms. Here we describe the first known small …

What do biologists want? If, unlike their counterparts in physics, biologists are generally
wary of a grand, overarching theory, at what kinds of explanation do biologists aim? How will …

The basic vertebrate body plan of the zebrafish embryo is established in the first 10 hours of
development. This period is characterized by the formation of the anterior-posterior and …

Somitogenesis is the basis of segmentation of the mesoderm in the trunk and tail of
vertebrate embryos. Two groups of mutants with defects in this patterning process have …

▪ Abstract The generation of distinct classes of neurons at defined positions within the
developing vertebrate nervous system depends on inductive signals provided by local cell …