Parental environmental factors, including diet, body composition, metabolism, and stress,
affect the health and chronic disease risk of people throughout their lives, as captured in the …

The steep rise of type 2 diabetes mellitus (T2DM) and associated complications go along
with mounting evidence of clinically important sex and gender differences. T2DM is more …

Reproductive longevity is essential for fertility and influences healthy ageing in women,, but
insights into its underlying biological mechanisms and treatments to preserve it are limited …

Extensive experimental animal studies and epidemiological observations have shown that
environmental influences during early development affect the risk of later pathophysiological …

Abstract Purpose of Review As the ongoing epidemic of adult and childhood obesity grows,
it puts a greater burden on individuals and the healthcare system due to increased …

Background The early life environment experienced by an individual in utero and during the
neonatal period is a major factor in shaping later life disease risk-including susceptibility to …

Diets rich in saturated fat produce inflammation, gliosis, and neuronal stress in the
mediobasal hypothalamus (MBH). Here, we show that microglia mediate this process and its …

Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …

Foetal development and infancy are life stages that are characterised by rapid growth,
development and maturation of organs and systems. Variation in the quality or quantity of …

Objectives To determine whether maternal obesity during pregnancy is associated with
increased mortality from cardiovascular events in adult offspring. Design Record linkage …