Cellular and molecular mechanisms linking human cortical development and evolution
B Libé-Philippot, P Vanderhaeghen - Annual review of genetics, 2021 - annualreviews.org
The cerebral cortex is at the core of brain functions that are thought to be particularly
developed in the human species. Human cortex specificities stem from divergent features of …
developed in the human species. Human cortex specificities stem from divergent features of …
Comparative cellular analysis of motor cortex in human, marmoset and mouse
The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals. Here, using high-throughput transcriptomic and epigenomic …
conserved across mammals. Here, using high-throughput transcriptomic and epigenomic …
Connectomic comparison of mouse and human cortex
The human cerebral cortex houses 1000 times more neurons than that of the cerebral cortex
of a mouse, but the possible differences in synaptic circuits between these species are still …
of a mouse, but the possible differences in synaptic circuits between these species are still …
[HTML][HTML] Human models are needed for studying human neurodevelopmental disorders
X Zhao, A Bhattacharyya - The American Journal of Human Genetics, 2018 - cell.com
The analysis of animal models of neurological disease has been instrumental in furthering
our understanding of neurodevelopment and brain diseases. However, animal models are …
our understanding of neurodevelopment and brain diseases. However, animal models are …
Innovations present in the primate interneuron repertoire
Primates and rodents, which descended from a common ancestor around 90 million years
ago, exhibit profound differences in behaviour and cognitive capacity; the cellular basis for …
ago, exhibit profound differences in behaviour and cognitive capacity; the cellular basis for …
Dendritic and axonal architecture of individual pyramidal neurons across layers of adult human neocortex
The size and shape of dendrites and axons are strong determinants of neuronal information
processing. Our knowledge on neuronal structure and function is primarily based on brains …
processing. Our knowledge on neuronal structure and function is primarily based on brains …
Identification of visual cortex cell types and species differences using single-cell RNA sequencing
The primate neocortex exerts high cognitive ability and strong information processing
capacity. Here, we establish a single-cell RNA sequencing dataset of 133,454 macaque …
capacity. Here, we establish a single-cell RNA sequencing dataset of 133,454 macaque …
Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouse
The primary motor cortex (M1) is essential for voluntary fine motor control and is functionally
conserved across mammals. Using high-throughput transcriptomic and epigenomic profiling …
conserved across mammals. Using high-throughput transcriptomic and epigenomic profiling …
[HTML][HTML] Primate neuronal connections are sparse in cortex as compared to mouse
Detailing how primate and mouse neurons differ is critical for creating generalized models of
how neurons process information. We reconstruct 15,748 synapses in adult Rhesus …
how neurons process information. We reconstruct 15,748 synapses in adult Rhesus …
A connectomic hypothesis for the hominization of the brain
JP Changeux, A Goulas, CC Hilgetag - Cerebral cortex, 2021 - academic.oup.com
Cognitive abilities of the human brain, including language, have expanded dramatically in
the course of our recent evolution from nonhuman primates, despite only minor apparent …
the course of our recent evolution from nonhuman primates, despite only minor apparent …