The consequences of overlapping G-quadruplexes and i-motifs in the platelet-derived growth factor receptor β core promoter nuclease hypersensitive element can …

RV Brown, T Wang, VR Chappeta, G Wu… - Journal of the …, 2017 - ACS Publications
The platelet-derived growth factor receptor β (PDGFR-β) signaling pathway is a validated
and important target for the treatment of certain malignant and nonmalignant pathologies …

Melting behavior of a DNA four-way junction using spectroscopic and calorimetric techniques

CE Carr, LA Marky - Journal of the American Chemical Society, 2017 - ACS Publications
Intramolecular four-way junctions are structures present during homologous recombination,
repair of double stranded DNA breaks, and integron recombination. Because of the wide …

[图书][B] The regulatory significance and molecular targeting of novel non-B-DNA secondary structures formed from the PDGFR-β core promoter nuclease …

RV Brown - 2014 - search.proquest.com
The precise regulation of PDGFR-β activity and expression is essential for mammalian
development and maintenance of homeostasis in the adult [1-3]. Aberrant expression that …

Site-selective characterization of the dynamics of the nucleic acid chaperone properties of HIV-1 nucleocapsid protein using innovative fluorescent probes

M Sholokh - 2016 - theses.hal.science
Due to its high conservation and key functions in the HIV-1 virus, the nucleocapsid protein
NC is a potential target for the development of new anti-viral drugs. Although the …