Trends in the discovery of new drugs for Mycobacterium tuberculosis therapy with a glance at resistance

V Lohrasbi, M Talebi, AZ Bialvaei, L Fattorini… - Tuberculosis, 2018 - Elsevier
Despite the low expensive and effective four-drug treatment regimen (isoniazid, rifampicin,
pyrazinamide and ethambutol) was introduced 40 years ago, TB continues to cause …

[HTML][HTML] Anti-tubercular peptides: A quest of future therapeutic weapon to combat tuberculosis

A Khusro, C Aarti, P Agastian - Asian Pacific Journal of Tropical Medicine, 2016 - Elsevier
Tuberculosis (TB) is a symbolic menace to mankind, infecting almost one third of the world's
populace and causing over a million mortalities annually. Mycobacterium tuberculosis (Mtb) …

Antimicrobial and structural properties of metal ions complexes with thiosemicarbazide motif and related heterocyclic compounds

E Namiecińska, M Sobiesiak, M Małecka… - Current Medicinal …, 2019 - ingentaconnect.com
Antibiotic resistance acquired by various bacterial fungal and viral pathogens poses
therapeutic problems of increasing severity. Among the infections that are very difficult to …

Cotreatment with clofazimine and rapamycin eliminates drug-resistant tuberculosis by inducing polyfunctional central memory T-cell responses

DK Singh, A Bhaskar, I Pahuja, A Shaji… - The Journal of …, 2023 - academic.oup.com
Mycobacterium tuberculosis, the causative agent of tuberculosis, is acquiring drug
resistance at a faster rate than the discovery of new antibiotics. Therefore, alternate …

[PDF][PDF] Hydrazones as a privileged structural linker in antitubercular agents: A review

B Mathew, J Suresh, MJ Ahsan… - … Current Drug Targets …, 2015 - researchgate.net
Hydrazones are a versatile linker of connecting various classes of organic compounds with
a unique structural feature of hydrogen bonding donor and the hydrogen bonding acceptor …

New heterobimetallic ferrocenyl derivatives: Evaluation of their potential as prospective agents against trypanosomatid parasites and Mycobacterium tuberculosis

F Rivas, A Medeiros, ER Arce, M Comini… - Journal of Inorganic …, 2018 - Elsevier
Searching for prospective agents against infectious diseases, four new ferrocenyl
derivatives,[M (L)(dppf) 4](PF 6), with M= Pd (II) or Pt (II), dppf= 1, 1′-bis …

Preparation, biological evaluation and molecular docking study of imidazolyl dihydropyrimidines as potential Mycobacterium tuberculosis dihydrofolate reductase …

NC Desai, AR Trivedi, VM Khedkar - Bioorganic & medicinal chemistry …, 2016 - Elsevier
A series of novel dihydropyrimidine derivatives bearing an imidazole nucleus at C-4 position
were synthesized in excellent yields via Biginelli multi-component reaction. The newly …

Synthesis and evaluation of functionalized benzoboroxoles as potential anti-tuberculosis agents

MA Alam, K Arora, S Gurrapu, SK Jonnalagadda… - Tetrahedron, 2016 - Elsevier
Several derivatives of aminobenzoboroxole have been prepared starting from 2-
boronobenzaldehyde. All of these derivatives have been evaluated for their anti …

Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity

B Villemagne, A Machelart, NC Tran… - ACS infectious …, 2020 - ACS Publications
Killing more than one million people each year, tuberculosis remains the leading cause of
death from a single infectious agent. The growing threat of multidrug-resistant strains of …

Do bioactive 8-hydroxyquinolines oxidovanadium (IV) and (V) complexes inhibit the growth of M. smegmatis?

G Scalese, Z Arhouma, K Kostenkova… - Journal of Inorganic …, 2022 - Elsevier
The antiproliferative effects of four series of V IV O-and VV O-based compounds containing 8-
hydroxyquinoline ligands on the bacterium Mycolicibacterium smegmatis (M. smeg) were …