Amongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) holds
particular interest due to distinctive properties including a normal restricted expression …

The immunopeptidome is the set of peptides presented by the major histocompatibility
complex (MHC) molecules, in humans also known as the human leukocyte antigen (HLA) …

How glucose metabolism remodels pro-tumor functions of tumor-associated macrophages
(TAMs) needs further investigation. Here we show that M2-like TAMs bear the highest …

Primary central nervous system lymphoma (PCNSL) is confined to the brain, eyes, and
cerebrospinal fluid without evidence of systemic spread. Rarely, PCNSL occurs in the …

CD4+ T cells orchestrate the adaptive immune response against pathogens and cancer by
recognizing epitopes presented on class II major histocompatibility complex (MHC-II) …

Cysteine cathepsins are a family of proteases that are relevant therapeutic targets for the
treatment of different cancers and other diseases. However, no clinically approved drugs for …

Follicular lymphoma (FL) represents a heterogeneous disease both clinically and
biologically. The pathognomonic t (14; 18) translocation can no longer be thought of as the …

Cysteine cathepsins, as the most abundant proteases found in the lysosomes, play a vital
role in several processes—such as protein degradation, changes in cell signaling, cell …

Follicular lymphoma (FL) is a neoplasm derived from germinal center B cells, composed of
centrocytes and centroblasts, with at least a focal follicular growth pattern. The t (14; 18) …

Background: Exposure to chronic psychological stress is a risk factor for metabolic
cardiovascular disease. Given the important role of lysosomal CTSS (cathepsin S) in human …