Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …

Aspirin (acetylsalicylic acid) has become one of the most commonly used drugs, given its
role as an analgesic, antipyretic and agent for cardiovascular prophylaxis. Several decades …

Cancer is a major health issue worldwide, and the global burden of cancer is expected to
increase in the coming years. Whereas the limited success with current therapies has driven …

Non-steroidal anti-inflammatory drugs (NSAIDs) are used chronically to reduce pain and
inflammation in patients with arthritic conditions, and also acutely as analgesics by many …

Malignant cells exhibit metabolic changes, when compared to their normal counterparts,
owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has …

Radiogenomics, focusing on the relationship between genomics and imaging phenotypes,
has been widely applied to address tumour heterogeneity and predict immune …

Importance The US Preventive Services Task Force recently recommended the use of
aspirin to prevent colorectal cancer and cardiovascular disease among many US adults …

Background Trastuzumab, a recombinant monoclonal antibody against HER2, has clinical
activity in advanced breast cancer that overexpresses HER2. We investigated its efficacy …

Abstract Background ASPirin in Reducing Events in the Elderly, a randomized, double-blind,
placebo-controlled trial of daily low-dose aspirin (100 mg) in older adults, showed an …

In most countries, healthcare service budgets are not likely to support the current explosion
in the cost of new oncology drugs. Repurposing the large arsenal of approved, non …