Background The skeleton plays a critical structural role in bearing functional loads, and
failure to do so results in fracture. As we evaluate new therapeutics and consider treatments …

Bone structure is an integral determinant of bone strength. The availability of high resolution
peripheral quantitative computed tomography (HR-pQCT) has made it possible to measure …

Typically, in the milder form of primary hyperparathyroidism (PHPT), now seen in most
countries, bone density by dual‐energy X‐ray absorptiometry (DXA) and detailed analyses …

Osteoporosis, a disease characterized by loss of bone mass and structural deterioration, is
currently diagnosed by dual-energy x-ray absorptiometry (DXA). However, DXA does not …

Developing effective treatment for osteoarthritis (OA), a prevalent and disabling disease, has
remained a challenge, primarily because of limited understanding of its pathogenesis and …

The microstructure of trabecular bone is usually perceived as a collection of plate-like and
rod-like trabeculae, which can be determined from the emerging high-resolution skeletal …

High‐resolution peripheral quantitative computed tomography (HR‐pQCT) is a new in vivo
imaging technique for assessing 3D microstructure of cortical and trabecular bone at the …

Publisher Summary This chapter introduces a series of contributions dealing with
osteoporosis in a wide variety of clinical settings. Its purpose is to consider the definition of …

Measurement of areal bone mineral density (aBMD) by dual‐energy x‐ray absorptiometry
(DXA) has been shown to predict fracture risk. High‐resolution peripheral quantitative …

Bone quality is a complex set of intricated and interdependent factors that influence bone
strength. A number of methods have emerged to measure bone quality, taking into account …