Synthetic approaches to biologically active C-2-substituted benzothiazoles

BA Shainyan, LV Zhilitskaya, NO Yarosh - Molecules, 2022 - mdpi.com
Numerous benzothiazole derivatives are used in organic synthesis, in various industrial and
consumer products, and in drugs, with a wide spectrum of biological activity. As the …

Green synthesis and biological evaluation of 6-substituted-2-(2-hydroxy/methoxy phenyl) benzothiazole derivatives as potential antioxidant, antibacterial and …

L Racané, L Ptiček, G Fajdetić, V Tralić-Kulenović… - Bioorganic …, 2020 - Elsevier
We present a new efficient green synthetic protocol for introduction of substituents to the C-6
position of 2-arylbenzothiazole nuclei. Newly synthesized compounds were designed to …

Applications of innovative synthetic strategies in anticancer drug Discovery: The Driving Force of new chemical reactions

H Wang, X Ma, L Sun, T Bi, W Yang - Bioorganic & Medicinal Chemistry …, 2025 - Elsevier
The discovery of novel anticancer agents remains a critical goal in medicinal chemistry, with
innovative synthetic methodologies playing a pivotal role in advancing this field. Recent …

Experimental and computational study of the antioxidative potential of novel nitro and amino substituted benzimidazole/benzothiazole-2-carboxamides with …

M Cindrić, I Sović, M Mioč, L Hok, I Boček, P Roškarić… - Antioxidants, 2019 - mdpi.com
We present the synthesis of a range of benzimidazole/benzothiazole-2-carboxamides with a
variable number of methoxy and hydroxy groups, substituted with nitro, amino, or amino …

Amidino substituted 2-aminophenols: Biologically important building blocks for the amidino-functionalization of 2-substituted benzoxazoles

L Ptiček, L Hok, P Grbčić, F Topić, M Cetina… - Organic & …, 2021 - pubs.rsc.org
Unlike the closely related and widely investigated amidino-substituted benzimidazoles and
benzothiazoles with a range of demonstrated biological activities, the matching benzoxazole …

Synthesis, antiproliferative and antitrypanosomal activities, and DNA binding of novel 6-amidino-2-arylbenzothiazoles

L Racané, V Rep, S Kraljević Pavelić… - Journal of enzyme …, 2021 - Taylor & Francis
A series of 6-amidinobenzothiazoles, linked via phenoxymethylene or directly to the 1, 2, 3-
triazole ring with ap-substituted phenyl or benzyl moiety, were synthesised and evaluated in …

Synthesis and antioxidative potency of novel amidino substituted benzimidazole and benzothiazole derivatives

L Racané, M Cindrić, N Perin, P Roškarić… - Croatica chemica …, 2017 - hrcak.srce.hr
Sažetak Herein we present the synthesis of versatile amidino substituted benzothiazole 3–
10 and benzimidazole 12–19 derivatives substituted with the variable number of hydroxy …

Eco-friendly synthesis, in vitro anti-proliferative evaluation, and 3D-QSAR analysis of a novel series of monocationic 2-aryl/heteroaryl-substituted 6-(2-imidazolinyl) …

L Racané, L Ptiček, M Sedić, P Grbčić… - Molecular …, 2018 - Springer
Abstract Herein, we describe the synthesis of twenty-one novel water-soluble monocationic
2-aryl/heteroaryl-substituted 6-(2-imidazolinyl) benzothiazole mesylates 3a–3u and present …

Novel methylselenoesters as antiproliferative agents

N Díaz-Argelich, I Encío, D Plano, AP Fernandes… - Molecules, 2017 - mdpi.com
Selenium (Se) compounds are potential therapeutic agents in cancer. Importantly, the
biological effects of Se compounds are exerted by their metabolites, with methylselenol …

Synthesis and Biological Activity of 2‐Benzo[b]thienyl and 2‐Bithienyl Amidino‐Substituted Benzothiazole and Benzimidazole Derivatives

L Racané, K Zlatić, M Cindrić, E Mehić… - …, 2023 - Wiley Online Library
Novel benzo [b] thienyl‐and 2, 2′‐bithienyl‐derived benzothiazoles and benzimidazoles
were synthesized to study their antiproliferative and antitrypanosomal activities in vitro …