Diarylureas: Repositioning from antitumor to antimicrobials or multi-target agents against new pandemics

A Catalano, D Iacopetta, M Pellegrino, S Aquaro… - Antibiotics, 2021 - mdpi.com
Antimicrobials have allowed medical advancements over several decades. However, the
continuous emergence of antimicrobial resistance restricts efficacy in treating infectious …

A comparative study of diaryl urea molecules with and without sulfonamide group on Carbonic anhydrase IX and XII inhibition and its consequence on breast cancer …

J Debnath, D Keshamasetthy, J Combs, K Leon… - Bioorganic …, 2024 - Elsevier
To investigate the intrinsic relation between carbonic anhydrase inhibition and anticancer
activity, we have prepared four sets of diaryl urea molecules and tested for the inhibition of …

β-Lactams and Ureas as Cross Inhibitors of Prokaryotic Systems

MI Konaklieva, BJ Plotkin - Applied Microbiology, 2023 - mdpi.com
β-Lactams in the last thirty years have been viewed as universal acylating agents of serine
and cysteine enzymes of both prokaryotic and eukaryotic systems. More recently, their use …

Oxovanadium (V)-Catalyzed Synthesis of Unsymmetrical Ureas by Activation of Carbon Dioxide under Ambient Pressure

T Matsutani, K Aoyama, T Moriuchi - Organometallics, 2023 - ACS Publications
A sustainable approach for the catalytic synthesis of unsymmetrical ureas from disilylamines
through catalytic activation of carbon dioxide as a C1 building block under ambient pressure …

The first attempt in synthesis, identification, and evaluation of SEPT9 inhibitors on human oral squamous carcinomas

HY Lai, KH Yu, KC Tsai, CC Lee, HY Wang… - Bioorganic …, 2025 - Elsevier
Abstract Septin 9 (SEPT9), a GTPase, known as the fourth cytoskeleton, is widely expressed
in various cells and tissues. The functions of SEPT9 are partly similar to other cytoskeletons …

[PDF][PDF] Diarylureas: Repositioning from Antitumor to Antimicrobials or Multi-Target Agents against New Pandemics. Antibiotics 2021, 10, 92

A Catalano, D Iacopetta, M Pellegrino, S Aquaro… - 2021 - academia.edu
Antimicrobials have allowed medical advancements over several decades. However, the
continuous emergence of antimicrobial resistance restricts efficacy in treating infectious …

2-Aryl benzazole derived new class of anti-tubercular compounds: Endowed to eradicate mycobacterium tuberculosis in replicating and non-replicating forms

AB Velappan, D Datta, R Ma, S Rana, KS Ghosh… - Bioorganic …, 2020 - Elsevier
The high mortality rate and the increasing prevalence of Mtb resistance are the major
concerns for the Tuberculosis (TB) treatment in this century. To counteract the prevalence of …

1, 3-Oxazine-2-one derived dual-targeted molecules against replicating and non-replicating forms of Mycobacterium tuberculosis

AB Velappan, D Kesamsetty, D Datta, R Ma… - European Journal of …, 2020 - Elsevier
The high mortality rate and increasing prevalence of resistant Mtb are the major concerns for
the Tuberculosis (TB) treatment in this century. To curtail the prevalence of resistant Mtb, we …

2-Methoxyphenyl isocyanate: a chemoselective multitasking reagent for an amine protection/deprotection sequence

AB Velappan, S Kogatam, D Datta, R Srithar… - Organic Chemistry …, 2019 - pubs.rsc.org
Organic amines, in general, are protected through carbamate bond mediated cappings.
Herein, we have demonstrated the chemically stable urea linkage suitably employed for …

1-[2-(1H-Pyrrole-2-carbonyl)phenyl]-3-(4-methoxyphenyl)urea

AG Sarantou, G Varvounis - Molbank, 2022 - mdpi.com
For the synthesis of 1-(2-(1 H-pyrrole-2-carbonyl) phenyl)-3-(4-methoxyphenyl) urea, the
final product, two different methods were used, in one or two steps, from (2-aminophenyl)(1 …