Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is a central method in
epigenomic research. Genome-wide analysis of histone modifications, such as enhancer …

An intricate molecular machinery is at the core of gene expression regulation in every cell.
During the initial stages of organismal development, the coordinated activation of diverse …

Abstract We recently introduced Cleavage Under Targets & Tagmentation (CUT&Tag), an
epigenomic profiling strategy in which antibodies are bound to chromatin proteins in situ in …

Next-generation sequencing (NGS) technologies have been used in diverse ways to
investigate various aspects of chromatin biology by identifying genomic loci that are bound …

Genomes encode for genes and non-coding DNA, both capable of transcriptional activity.
However, unlike canonical genes, many transcripts from non-coding DNA have limited …

The molecular mechanisms that regulate the rapid transcriptional changes that occur during
cytotoxic T lymphocyte (CTL) proliferation and differentiation in response to infection are …

Chromatin immunoprecipitation followed by sequencing (ChIP-seq) analysis can detect
protein/DNA-binding and histone-modification sites across an entire genome. Recent …

The most striking characteristic of CHO cells is their adaptability, which enables efficient
production of proteins as well as growth under a variety of culture conditions, but also results …

The advent of high throughput next generation sequencing (NGS) has accelerated the pace
of discovery of disease-associated genetic variants and genomewide profiling of expressed …

Plants can produce organs throughout their entire life from pluripotent stem cells located at
their growing tip, the shoot apical meristem (SAM). At the time of flowering, the SAM of …