Gene therapy has been experiencing a breakthrough in recent years, targeting various
specific cell groups in numerous therapeutic areas. However, most recent clinical studies …

The toolbox for genetic engineering has quickly evolved from CRISPR/Cas9 to a myriad of
different gene editors, each with promising properties and enormous clinical potential …

It is a complex disease with multiple pathogenesis that causes pulmonary hypertension
(PH). In addition to the commonly used drugs for treating PH, pharmacogenomic therapies …

The aging population contributes to an increase in the prevalence of neurodegenerative
diseases, such as Parkinson's disease (PD). Due to the progressive nature of these …

The therapeutic and research potentials of oligonucleotides (ONs) have been hampered in
part by their inability to effectively escape endosomal compartments to reach their cytosolic …

The advances in the field of gene therapy have significantly improved the possibility for
nucleic acids as highly promising agents for the treatment of both inherited and acquired …

Nucleic acid molecules can be transferred into cells to alter gene expression and, thus,
alleviate certain pathological conditions. Cell-penetrating peptides (CPPs) are vectors that …

Non-viral transfection reagents are continuously being developed in attempt to replace viral
vectors. Among those non-viral vectors, dendrimers have gained increasing interest due to …

Titanium is the metal of choice for dental implants because of its biocompatibility and ability
to merge with human bone tissue. Despite the great success rate of dental implants, early …

This Chapter summarizes the methods for CPP-conjugated oligonucleotide-based agents
with the potential to use as the therapeutic drugs. The methods for gene silencing (or …