What's new in adipocytic neoplasia?

K Thway - Histopathology, 2022 - Wiley Online Library
Adipocytic tumours are among the most common mesenchymal neoplasms, and constitute a
clinically, biologically and pathologically diverse group. Their wide histological spectrum …

[HTML][HTML] Whole-genome sequencing reveals mutational signatures related to radiation-induced sarcomas and DNA-damage-repair pathways

E Kim, DJ Han, BH Kim, J Yoo, HJ Kim, HG Wu… - Modern Pathology, 2023 - Elsevier
Radiation-induced sarcoma (RIS) is a rare but serious late complication arising from
radiotherapy. Despite unfavorable clinical outcomes, the genomic footprints of ionizing …

Clinical utility of anchored multiplex solid fusion assay for diagnosis of bone and soft tissue tumors

I Chebib, MS Taylor, V Nardi, MN Rivera… - The American Journal …, 2021 - journals.lww.com
Sarcoma diagnosis has become increasingly complex, requiring a combination of
morphology, immunohistochemistry, and molecular studies to derive specific diagnoses. We …

High prevalence of TERT aberrations in myxoid liposarcoma: TERT reactivation may play a crucial role in tumorigenesis

J Kunieda, K Yamashita, Y Togashi, S Baba… - Cancer …, 2022 - Wiley Online Library
Myxoid liposarcoma (MLPS) is genetically characterized by FUS‐DDIT3 or EWSR1‐DDIT3
gene fusion and the high frequency of hotspot mutations (C228T or C250T) in the promoter …

Case report: identification of multiple TERT and FGFR2 gene fusions in a pineal region glioblastoma case

X Guo, T Chen, S Chen, C Song, D Shan, S Xu… - Frontiers in …, 2021 - frontiersin.org
As an oncogenic somatic variant, telomerase reverse transcriptase promoter (TERTp)
mutations are frequently observed in adult glioblastoma (GBM). Alternatively, we report the …

Vanished MDM2 amplification in multiple recurrences of an irradiated poorly differentiated sarcoma with amplified TRIO::TERT fusion gene

S Goffinet, I Di Mauro, J Doyen, J Boyer… - Genes …, 2023 - Wiley Online Library
Among sarcomas, MDM2 amplification is usually a molecular hallmark of well‐differentiated
liposarcoma and dedifferentiated liposarcoma (DDLPS) and occasionally a secondary …

Locally advanced undifferentiated sarcomatoid carcinoma of the right maxillary sinus with PDCD6-TERT fusion: A rare case report

L Zhang, L Chen, M Xiao, X Xie, F Wang - Oral Oncology, 2022 - Elsevier
Sarcomatoid carcinoma of maxillary sinus tumor is extremely rare in head and neck tumors
and has poor prognosis and frequently occurs to relapse locally after surgery. We first …

TERT gene rearrangement in chordomas and comparison to other TERT-rearranged solid tumors

JY Yoon, W Jiang, CR Orr, C Rushton, S Gargano… - Cancer Genetics, 2021 - Elsevier
Chordomas are rare, slow-growing neoplasms thought to arise from the foetal notochord
remnant. A limited number of studies that examined the mutational profiles in chordomas …

Whole-genome Sequencing Reveals Comprehensive Genomic Profiles of Radiation Induced Sarcomas

김은지 - 2021 - s-space.snu.ac.kr
Background and Purpose: Radiation-induced sarcoma (RIS) is a rare secondary malignancy
that is caused by treatment-related ionizing radiation after a long latency period. Despite …