Aurora kinases are serine/threonine kinases essential for the onset and progression of
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …

Rare hereditary disorders provide unequivocal evidence of the importance of genes in
human disease pathogenesis. Familial syndromes that predispose to osteosarcomagenesis …

Epigenetic and epitranscriptomic networks have important functions in maintaining the
pluripotency of embryonic stem cells (ESCs) and somatic cell reprogramming. However, the …

In vitro modeling of human disease has recently become feasible with induced pluripotent
stem cell (iPSC) technology. Here, we established patient-derived iPSCs from a Li-Fraumeni …

Centrosome-localized mitotic Aurora kinase A (AURKA) facilitates G2/M events. Here we
show that AURKA translocates to the nucleus and causes distinct oncogenic properties in …

In this study, we outline a regulatory network that involves the p53 tumor suppressor family
and the Wnt pathway acting together with the TGF-β pathway in mesendodermal …

Pluripotent stem cells (PSCs) proliferate rapidly with a characteristic cell cycle structure
consisting of short G1-and G2-gap phases. This applies broadly to PSCs of peri-implantation …

Most human cancers harbor mutations in the gene encoding p53. As a result, research on
p53 in the past few decades has focused primarily on its role as a tumor suppressor. One …

Stem cell senescence contributes to stem cell exhaustion and drives various aging‐
associated disorders. However, strategies to rejuvenate senescent stem cells are limited …

Abstract The Cancer Genome Atlas (TCGA) has accrued RNA-Seq-based transcriptome
data for more than 4000 cancer tissue samples across 12 cancer types, translating these …