Nuclear factor-κB (NF-κB) transcription factors play a key role in the pathogenesis of multiple
myeloma (MM). The survival, proliferation and chemoresistance of malignant plasma cells …

Despite enormous advances in terms of therapeutic strategies, multiple myeloma (MM) still
remains an incurable disease with MM patients often becoming resistant to standard …

Introduction T-cell acute lymphoblastic leukemia is characterized by its fast progression rate
and high complications. TRAIL can be used to trigger apoptosis in cancer cells with minimal …

Mitochondria, the organelle critical for cell survival and metabolism, are exploited by cancer
cells and provide an important therapeutic target in cancers. Mitochondria dynamically …

Introduction Methotrexate (MTX), a folic acid antagonist and nucleotide synthesis inhibitor, is
a cornerstone drug used against acute lymphoblastic leukemia (ALL), but its mechanism of …

Multiple myeloma (MM) is a common hematological malignancy. Although recent clinical
applications of immunomodulatory drugs, proteasome inhibitors and CD38-targeting …

Fas-associated death domain (FADD) is an adaptor protein that predominantly transduces
the apoptosis signal from the death receptor (DR) to activate caspases, leading to the …

Background: Uncontrolled cell growth and proliferation, which originate from lung tissue
often lead to lung carcinoma and are more likely due to smoking as well as inhaled …

Splenic diffuse red pulp small B-cell lymphoma (SDRPL) is a rare B-cell tumor whose
genetic characteristics are poorly understood. Here, we introduce the case of a 62-year-old …

Abstract The Fas associated Death Domain (FADD) is an adaptor protein that predominantly
transduces apoptosis signal from death receptor (DR) to activate caspases, leading to the …