Organismal aging exhibits wide-ranging hallmarks in divergent cell types across tissues,
organs, and systems. The advancement of single-cell technologies and generation of rich …

Abstract The National Genomics Data Center (NGDC), part of the China National Center for
Bioinformation (CNCB), provides a family of database resources to support global research …

Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …

Abstract Epigenome-Wide Association Study (EWAS) has become a standard strategy to
discover DNA methylation variation of different phenotypes. Since 2018, we have developed …

Significant progress in the diagnosis and treatment of cardiovascular disease (CVD) has
been made in the past decade, yet it remains a leading cause of morbidity and mortality …

DNA methylation, as the most intensively studied epigenetic mark, regulates gene
expression in numerous biological processes including development, aging, and disease …

Single-cell multimodal sequencing parallelly captures multiple modalities of the same cell,
providing unparalleled insights into cell heterogeneity and cell dynamics. For example, joint …

Oxidative (or respiratory) burst confers host defense against pathogens by generating
reactive species, including reactive nitrogen species (RNS). The microbial infection-induced …

Simple Summary Cancer is a distinctly difficult disease to treat on account of the diverse cell
populations/subpopulations that comprise a tumour. Such cells harbour varying genetic and …

Background Mammalian ste20‐like kinase 4 (MST4) and autophagy have been implicated
in ailments such as inflammatory and cancers. Methods In this study, the expression of …