Many antibiotics available in the clinic today directly inhibit bacterial translation. Despite the
past success of such drugs, their efficacy is diminishing with the spread of antibiotic …

Kutzneria is a rare genus of Actinobacteria that harbors a variety of secondary metabolite
gene clusters and produces several interesting types of bioactive secondary metabolites …

Free radical carbochloromethylations of ortho-cyanoarylacrylamides and N-(arylsulfonyl)
acrylamides have been developed by employing simple alkyl chlorides as the chloromethyl …

Chloramphenicol (CAM), the bacteriostatic broad-spectrum antibiotic, isolated from
Streptomyces venezuelae during the “golden era” of antibiotic discovery, nowadays has …

Free radical initiated bicyclization of 1, 6-enynes with chloralkanes, is achieved via selective
activation of the C (sp3)–H bond of the chloralkane, resulting in diverse polychlorinated …

Intrinsic resistance in Pseudomonas aeruginosa, defined by chromosomally encoded low
outer membrane permeability and constitutively over-expressed efflux pumps, is a major …

Although aminoglycoside antibiotics are effective against Gram-negative infections, these
drugs often cause irreversible hearing damage. Binding to the decoding site of the …

Each year, infections caused by fungal pathogens claim the lives of about 1.6 million people
and affect the health of over a billion people worldwide. Among the most recently developed …

A general Cu-catalyzed strategy for coupling cyclic imides and alkenylboronic acids by
forming C (sp2)–N-bonds is reported. The method enables the practical and mild …

In a previous study published by our group, successful modification of the antibiotic
chloramphenicol (CHL) was reported, which was achieved by replacing the dichloroacetyl …