The multiplex model of the genetics of Alzheimer's disease
Genes play a strong role in Alzheimer's disease (AD), with late-onset AD showing heritability
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …
Diagnosis and management of dementia
Z Arvanitakis, RC Shah, DA Bennett - Jama, 2019 - jamanetwork.com
Importance Worldwide, 47 million people live with dementia and, by 2050, the number is
expected to increase to 131 million. Observations Dementia is an acquired loss of cognition …
expected to increase to 131 million. Observations Dementia is an acquired loss of cognition …
Implementation of subjective cognitive decline criteria in research studies
Introduction Subjective cognitive decline (SCD) manifesting before clinical impairment could
serve as a target population for early intervention trials in Alzheimer's disease (AD). A …
serve as a target population for early intervention trials in Alzheimer's disease (AD). A …
Alzheimer's disease: a brief history of immunotherapies targeting amyloid β
ACS Vogt, GT Jennings, MO Mohsen, M Vogel… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common form of dementia and may contribute to 60–
70% of cases. Worldwide, around 50 million people suffer from dementia and the prediction …
70% of cases. Worldwide, around 50 million people suffer from dementia and the prediction …
[HTML][HTML] Diagnostic biomarkers of Alzheimer's disease: a state-of-the-art review
R Khoury, E Ghossoub - Biomarkers in Neuropsychiatry, 2019 - Elsevier
In 2018, there was a recent shift towards a biological definition of Alzheimer's disease (AD),
based on biomarkers measured in vivo even before the onset of clinical dementia …
based on biomarkers measured in vivo even before the onset of clinical dementia …
GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
The complex nature of human cognition has resulted in cognitive genomics lagging behind
many other fields in terms of gene discovery using genome-wide association study (GWAS) …
many other fields in terms of gene discovery using genome-wide association study (GWAS) …
Remote blood biomarkers of longitudinal cognitive outcomes in a population study
Objective The longitudinal association of the blood biomarkers total tau (t‐tau),
neurofilament light (Nf‐L), and glial fibrillary acidic protein (GFAP) with common sporadic …
neurofilament light (Nf‐L), and glial fibrillary acidic protein (GFAP) with common sporadic …
Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer's disease
The dominant hypothesis of Alzheimer's disease (AD) aetiology, the neuropathological
guidelines for diagnosing AD and the majority of high-profile therapeutic efforts, in both …
guidelines for diagnosing AD and the majority of high-profile therapeutic efforts, in both …
Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age
In advanced age, some individuals maintain a stable cognitive trajectory while others
experience a rapid decline. Such variation in cognitive trajectory is only partially explained …
experience a rapid decline. Such variation in cognitive trajectory is only partially explained …
The association between vision impairment and incidence of dementia and cognitive impairment: a systematic review and meta-analysis
Topic The magnitude and direction of the association between vision impairment and
incident dementia and cognitive impairment in prospective cohort studies was estimated by …
incident dementia and cognitive impairment in prospective cohort studies was estimated by …