Breast cancer rises as the most commonly diagnosed cancer in 2020. Among women,
breast cancer ranks first in both cancer incidence rate and mortality. Treatment resistance …

Over three decades have passed since the first report on the expression of CA125 by
ovarian tumors. Since that time our understanding of ovarian cancer biology has changed …

Introduction: Mesothelin (MSLN) is a tumor differentiation antigen normally restricted to the
body's mesothelial surfaces, but significantly overexpressed in a broad range of solid …

Malignant mesothelioma (MM) is a treatment-resistant tumor originating in the mesothelial
lining of the pleura or the abdominal cavity with very limited treatment options. More effective …

Immuno-positron emission tomography (immunoPET) is a molecular imaging modality
combining the high sensitivity of PET with the specific targeting ability of monoclonal …

Ovarian cancer (OC) causes significant morbidity and mortality as neither detection nor
screening of OC is currently feasible at an early stage. Difficulty to promptly diagnose OC in …

Immunotoxins are cytolytic fusion proteins developed for cancer therapy, composed of an
antibody fragment that binds to a cancer cell and a protein toxin fragment that kills the cell …

Simple Summary This review summarizes the current knowledge on mesothelin's function,
its role in cancer, and opportunities for immunotherapeutic targeting of mesothelin …

Cholangiocarcinomas (CCAs) are diverse epithelial tumors arising from the liver or large
bile ducts with features of cholangiocyte differentiation. CCAs are classified anatomically …

Recombinant immunotoxins (RIT s) are chimeric proteins designed to treat cancer. They are
made up of an Fv or Fab that targets an antigen on a cancer cell fused to a 38‐kDa portion of …