Introduction: The gastrointestinal mucosa constitutes a critical barrier where millions of
microbes and environmental antigens come in close contact with the host immune system …

The rapidly declining prevalence of Helicobacter pylori infection and widespread use of
potent anti-secretory drugs means peptic ulcer disease has become substantially less …

The gut microbiota has diverse and essential roles in host metabolism, development of the
immune system and as resistance to pathogen colonization. Perturbations of the gut …

Nonsteroidal anti-inflammatory drugs (NSAIDs) can damage the gastrointestinal tract,
causing widespread morbidity and mortality. Although mechanisms of damage involve the …

Proton pump inhibitors (PPIs) are common medications within the practice of
gastroenterology. These drugs, which act through the irreversible inhibition of the …

The composition of the gut microbiome with the use of non-steroidal anti-inflammatory drugs
(NSAIDs) has not been fully characterized. Drug use within the past 30 days was …

Background Global prescription drug use has been increasing continuously for decades.
The gut microbiome, a key contributor to health status, can be altered by prescription drug …

Background & Aims Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) or low-
dose aspirin is associated with increased risk of upper gastrointestinal bleeding. There is …

Nonsteroidal anti-inflammatory drugs (NSAID) s relieve pain, inflammation, and fever by
inhibiting the activity of cyclooxygenase isozymes (COX-1 and COX-2). Despite their clinical …

NSAIDs are widely used to treat pain and rheumatic conditions, but they induce adverse
events in different body systems, although the major, most frequent events occur in the …