The skeletal system is the third most common site for cancer metastases, surpassed only by
the lungs and liver. Many tumors, especially those of the breast, prostate, lungs, and …

The use of radionuclides in medicine is based largely on the discoveries of two critical
concepts, the “tracer principle” and the “magic bullet”. In 1913, George de Hevesy …

The high concentration of mineral present in bone and pathological calcifications is unique
compared with all other tissues and thus provides opportunity for targeted delivery of …

Since their discovery over 100years ago, bisphosphonates have been used industrially as
corrosion inhibitors and complexing agents. With the discovery of their pharmacological …

Radionuclide therapy (RNT) based on the concept of delivering cytotoxic levels of radiation
to disease sites is one of the rapidly growing fields of nuclear medicine. Unlike conventional …

PURPOSE In 2017, Cancer Care Ontario's Program in Evidence-Based Care released the
Bone Health and Bone-Targeted Therapies for Prostate Cancer guideline. This guideline …

Background Bone metastases occur frequently in patients with advanced cancer and are a
serious complication of cancer. The decision to treat is often individualized, based on each …

Radiofrequency ablation (RFA) and vertebral augmentation is an emerging combination
therapy for painful osseous metastases that cannot be or are incompletely palliated with …

Nuclear medicine continues to represent one of the important modalities for cancer
management. While diagnostic nuclear medicine for cancer management is fairly well …

Targeted radiotherapy is an evolving and promising modality of cancer treatment. The killing
of cancer cells is achieved with the use of biological vectors and appropriate radionuclides …