[HTML][HTML] The coding capacity of SARS-CoV-2

Y Finkel, O Mizrahi, A Nachshon… - Nature, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing
coronavirus disease 2019 (COVID-19) pandemic 1. To understand the pathogenicity and …

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier… - Nature, 2020 - nature.com
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …

Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike …

AD Davidson, MK Williamson, S Lewis, D Shoemark… - Genome medicine, 2020 - Springer
Background SARS-CoV-2 is a recently emerged respiratory pathogen that has significantly
impacted global human health. We wanted to rapidly characterise the transcriptomic …

The rationale for potential pharmacotherapy of COVID-19

M Saber-Ayad, MA Saleh, E Abu-Gharbieh - Pharmaceuticals, 2020 - mdpi.com
On 11 March 2020, the coronavirus disease (COVID-19) was defined by the World Health
Organization as a pandemic. Severe acute respiratory syndrome-2 (SARS-CoV-2) is the …

SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes

D Bojkova, JUG Wagner, M Shumliakivska… - Cardiovascular …, 2020 - academic.oup.com
Aims Coronavirus disease 2019 is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and has emerged as a global pandemic. SARS-CoV-2 …

SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes

I Jungreis, R Sealfon, M Kellis - Nature communications, 2021 - nature.com
Despite its clinical importance, the SARS-CoV-2 gene set remains unresolved, hindering
dissection of COVID-19 biology. We use comparative genomics to provide a high …

Utility of proteomics in emerging and re-emerging infectious diseases caused by RNA viruses

M Sperk, R Van Domselaar, JE Rodriguez… - Journal of Proteome …, 2020 - ACS Publications
Emerging and re-emerging infectious diseases due to RNA viruses cause major negative
consequences for the quality of life, public health, and overall economic development. Most …

[HTML][HTML] Lack of antiviral activity of darunavir against SARS-CoV-2

S De Meyer, D Bojkova, J Cinatl, E Van Damme… - International Journal of …, 2020 - Elsevier
Objectives Given the high need and the absence of specific antivirals for treatment of COVID-
19 (the disease caused by severe acute respiratory syndrome-associated coronavirus-2 …

Direct RNA sequencing and early evolution of SARS-CoV-2

G Taiaroa, D Rawlinson, L Featherstone, M Pitt, L Caly… - BioRxiv, 2020 - biorxiv.org
Fundamental aspects of SARS-CoV-2 biology remain to be described, having the potential
to provide insight to the response effort for this high-priority pathogen. Here we describe the …

[HTML][HTML] Growth factor receptor signaling inhibition prevents SARS-CoV-2 replication

K Klann, D Bojkova, G Tascher, S Ciesek, C Münch… - Molecular cell, 2020 - cell.com
SARS-CoV-2 infections are rapidly spreading around the globe. The rapid development of
therapies is of major importance. However, our lack of understanding of the molecular …